Results 71 to 80 of about 485,392 (348)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Rational use of inhaled corticosteroids for the treatment of COPD: a plain language summary

Journal of Comparative Effectiveness Research, 2023
What is this summary about? Inhaled corticosteroids (ICS) are a type of medication delivered via an inhaler device that are commonly used in the treatment of asthma.
Amnon Ariel, Peter J Barnes, Tiago Maricoto, Miguel Román-Rodríguez, Andy Powell, Jennifer K Quint   +5 more
doaj   +1 more source

A plain language summary about a cell cycle-based, new surveillance mechanism against cancer

Future Oncology
Plain Language Summary What is this summary about? This is a plain language summary about a new mechanism on how our body selectively looks for any unusual cells that might turn into cancer.
Albert Qin
semanticscholar   +1 more source

A Foundation for Online Knowledge Mobilization in Child and Youth Mental Health: Synthesis Report [PDF]

, 2014
Navigating the online environment to find mental health can be a daunting task, especially for children and youth. Three research projects commissioned by the Mental Health Commission of Canada were summarized in this report. The projects sought insights

core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Complete response to pembrolizumab in a paediatric patient with Lynch syndrome-associated colorectal cancer: a case report and review of immunotherapy-related bowel obstruction

Drugs in Context
Colorectal cancer (CRC) is extremely rare in paediatrics with aggressive histopathology and advanced presentation. Whilst pembrolizumab has shown efficacy in adult microsatellite instability-high or mismatch repair deficiency CRC, paediatric data remain ...
Antonio Ruggiero, Fernando Fuccillo, Palma Maurizi, Alberto Romano, Dario Talloa, Stefano Mastrangelo, Michele Basso, Vito Briganti, Maria Cristina Giustiniani, Roberto Persiani, Giorgio Attinà   +10 more
doaj   +1 more source

Amyloid-related imaging abnormalities (ARIA) and their radiological, biological and clinical characteristics: a plain language summary

Neurodegenerative Disease Management
Plain language summary What is this summary about? This is a plain language summary of an article published in the journal Brain. People with Alzheimer's disease may receive treatments that target amyloid-β – a protein in the brain that is one of the key
Harald Hampel, Aya Elhage, M. Cho, James Ar Nicoll, Alireza Atri   +4 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Role of a topical hydrogel (Dermatix® wound care gel) in acute and chronic wound management: a case series of real-world experiences and expert opinion from Asia

Drugs in Context
Moist wound healing, an established paradigm in the management of wounds, accelerates healing by maintaining an optimal microenvironment. Hydrogels, such as the Dermatix®* Wound Care (DWC) gel, possess fluid-retentive and absorptive properties and ...
Chin Yen Lee, Elizabeth Wei Hsi Chang, Khong Yik Chew, Vilvkumaran Karupayah, Wildan Latief, Vi Anh Le, Dohar Tobing, Thi Phuong Thao Vu, Kean Chew Wong   +8 more
doaj   +1 more source

Plain language summary of the KarMMa-3 study of ide-cel or standard of care regimens in people with relapsed or refractory multiple myeloma

Future Oncology
Plain language summary What is this summary about? This plain language summary describes the results of a Phase 3 study called KarMMa-3. In this ongoing study, researchers looked at a relatively new treatment for people with multiple myeloma, a type of ...
P. Rodríguez-Otero, S. Ailawadhi, B. Arnulf, Krina K Patel, M. Cavo, Ajay K Nooka, S. Manier, Natalie S. Callander, Luciano J. Costa, Ravi Vij, Nizar J. Bahlis, P. Moreau, Scott R Solomon, Michel Delforge, J. Berdeja, A. Truppel-Hartmann, Zhihong Yang, L. Favre‐Kontula, Fan Wu, J. Piasecki, Mark Cook, Sergio Giralt   +21 more
semanticscholar   +1 more source