Results 91 to 100 of about 485,392 (348)

Effectiveness of tenapanor for treating hyperphosphatemia in patients receiving dialysis: a plain language summary of the OPTIMIZE study

open access: yesCurrent Medical Research and Opinion
Plain Language Summary What is this summary about? This summary provides a review of the OPTIMIZE study, the results of which were published in Kidney360 in February 2024.
Stuart M. Sprague   +5 more
semanticscholar   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Tr14 gel for the treatment of acute ankle sprains: a plain language summary of the TRAUMED trial

open access: yesJournal of Comparative Effectiveness Research
What is this summary about? This is a summary of an article discussing the results of the TRAUMED trial, which was originally published in the Journal of Clinical Medicine.
Ludger Gerdesmeyer   +5 more
doaj   +1 more source

Safety of Maternal Immunization Against Pertussis: A Systematic Review

open access: yesInfectious Diseases and Therapy, 2019
The WHO recommends vaccination of all children against pertussis. However, newborn infants remain vulnerable to infection. Pertussis vaccination during pregnancy has been introduced in several countries to protect newborns via transplacental transfer of ...
Caroline D’Heilly   +2 more
doaj   +1 more source

Acoustic cues for the korean stop contrast-dialectal variation [PDF]

open access: yes, 2013
In this study, cross-dialectal variation in the use of the acoustic cues of VOT and F0 to mark the laryngeal contrast in Korean stops is examined with Chonnam Korean and Seoul Korean.
Choi, Hansook
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Long-term effectiveness and safety of ravulizumab in paroxysmal nocturnal hemoglobinuria: a plain language summary

open access: yesJournal of Comparative Effectiveness Research
What is this summary about? Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease where red blood cells break apart because they lack certain protective proteins.
Celso Arrais   +2 more
doaj   +1 more source

Apremilast in osteoarthritis: exploring its therapeutic mechanisms

open access: yesDrugs in Context
Osteoarthritis (OA) is increasingly understood as a complex, inflammatory disease rather than a purely mechanical disorder. Apremilast, a selective phosphodiesterase 4 inhibitor approved for psoriatic arthritis, is amongst several new treatment ...
Farzad Rafiei   +4 more
doaj   +1 more source

So What If I\u27m Gonna Hurt Myself: The ADA\u27s Direct Threat Defense [PDF]

open access: yes, 2003
A high-beam walking ironworker atop a skyscraper develops a severe case of vertigo. A power saw operator develops narcolepsy. Must the employers of these individuals with disabilities tolerate the risk that they pose to their own safety in fear of facing
Lucas, Tory L.
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

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