Results 91 to 100 of about 57,146 (267)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Plain language summary for "Effective GH Replacement with Somapacitan in Children with GHD: REAL4 2-year Results and after Switch from Daily GH"

, 2023
Plain language summary for "Effective GH Replacement with Somapacitan in Children with GHD: REAL4 2-year Results and after Switch from Daily GH"
Rikke Beck Bang (16459941), Joanne Blair (9991035), Michel Polak (9991049), Jun Mori (701859), Reiko Horikawa (393659), Volker Böttcher (16459940), Michael Højby Rasmussen (14699299), Ho-Seong Kim (286495), Bradley S. Miller (12162545), Aristides K Maniatis (14172119)   +9 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Japanese translation of: Plain language summary of results from the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

, 2022
Japanese translation of: Plain language summary of results from the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial ...
Costa, Nuno, Srikala S. Sridhar (9859362), Yohann Loriot (342267), Joaquim Bellmunt (514168), Eric Voog (13915535), Demey, Wim, Wim Demey (5997533), Caserta, Claudia, Blake-Haskins, John A, Claudia Caserta (5488349), Evgeny Kopyltsov (13915529), Anders Ullén (5997569), Begoña P. Valderrama (13915532), Sinisa Radulović (1713037), Bellmunt, Joaquim, Gurney, Howard, Voog, Eric, Robert J. Laliberte (13915527), Valderrama, Begoña P, John A. Blake-Haskins (13915521), Powles, Thomas, Petros Grivas (5845325), Tsuchiya, Norihiko, Laliberte, Robert J, Howard Gurney (9902205), Sridhar, Srikala S, Petrylak, Daniel P, Nuno Costa (174527), Thomas Powles (3502598), Radulovic, Sinisa, Se-Hoon Park (392972), Bo Huang (30906), Norihiko Tsuchiya (95704), Ullén, Anders, Grivas, Petros, Haralabos Kalofonos (3570197), Park, Se Hoon, Loriot, Yohann, Kopyltsov, Evgeny, Sternberg, Cora N, Huang, Bo, Kalofonos, Haralabos, Cora N. Sternberg (5986232), Jeanny B. Aragon-Ching (13915528), Aragon-Ching, Jeanny B, Daniel P. Petrylak (2657491)   +45 more
core   +1 more source

Sphingosine-1-phosphate receptor modulators in ulcerative colitis – a narrative review of current evidence and practical considerations

Drugs in Context
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with a relapsing and remitting course often necessitating the use of advanced therapy to maintain disease control. Sphingosine-1-phosphate receptor modulators (S1PRMs) represent a new class
Anish J Kuriakose Kuzhiyanjal, Karishma Sethi-Arora, Gaurav B Nigam, Jimmy K Limdi   +3 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Snapshot - a lay language summary on families of military veterans [PDF]

, 2019
A plain language summary of research and evidence relating to the UK Armed Forces and veteran ...
Cooper, Linda
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Treatment preferences of people with hemophilia and caregivers: a plain language summary

Therapeutic Advances in Hematology
Summary What is this summary about? This is a summary of the results from a study that looked at the treatment preferences of people with hemophilia and caregivers of children with hemophilia in the US and UK.
Hui Lu, Travis Gould, Carmine Colavecchia, Joshua Coulter, Lisa J. Wilcox, Joseph C. Cappelleri, Stephanie A. Christopher, Brett Hauber, Álvaro Alberto Gutiérrez-Vargas, Nicola Dunn, Pratima Chowdary, Jennifer A. Whitty   +11 more
doaj   +1 more source

Apremilast in osteoarthritis: exploring its therapeutic mechanisms

Drugs in Context
Osteoarthritis (OA) is increasingly understood as a complex, inflammatory disease rather than a purely mechanical disorder. Apremilast, a selective phosphodiesterase 4 inhibitor approved for psoriatic arthritis, is amongst several new treatment ...
Farzad Rafiei, Saina Sadeghipour, Seyed Mohammad Hosseini Marvast, Ali Mandegary, Hamidreza Soltani   +4 more
doaj   +1 more source