Results 151 to 160 of about 1,588,042 (310)

Le développement de l’employabilité, outil pour limiter l’inadéquation formation emploi : Cas du métier d’un responsable financier

Revue Marocaine de Recherche en Management et Marketing, 2016
Cet article se propose d’étudier l’impact du développement de l’employabilité sur la limitation de l’inadéquation entre la formation et le marché de l’emploi.
YASSINE HILMI , MOUNA HILMI
doaj  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Amyloïdose cutanée nodulaire localisée consécutive à des injections d’insuline chez une femme de 40 ans. [PDF]

CMAJ
Zhuang M, Vaziri M, Sandhu N.
europepmc   +1 more source

Elaborer un plan de recrutement et de formation pour les animateurs périscolaires

, 2014
Cet article trouve son origine dans la journée d'étude "Aménagement des rythmes scolaires et animation" organisée par le département Carrières Sociales de l'I.U.T. de Nice en mars 2014 à Menton Soucieux des nécessités réglementaires, des besoins de fonctionnement et des difficultés pour recruter des personnels qualifiés, l'article propose une ...
openaire   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In-depth 3D exploration of autosomal dominant polycystic kidney disease through light sheet fluorescence microscopy. [PDF]

Sci Rep
Delgado-Rodriguez P, Vitoria I, Ríos-Muñoz GR, Bardia L, Lamanna-Rama N, Nicolas-Saenz L, Sporring J, Soto-Montenegro ML, Aldabe R, Colombelli J, Muñoz-Barrutia A.   +10 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Promouvoir le bien-être des médecins membres du personnel au Canada. [PDF]

CMAJ
Do V, Lewis M, Li H.
europepmc   +1 more source