Results 61 to 70 of about 141,844 (268)

O PDE e as metas do PAR para a formação de professores da educação básica El PDE y las metas del par para la formación de profesores de la educación básica The PDE and the goals of par for the teachers'formation of basic education

Ensaio, 2012
Este trabalho analisa a política de regulação do Plano de Desenvolvimento da Educação (PDE) considerando as ações do Plano de Ações Articuladas (PAR) como indutoras de melhoria da qualidade na educação básica.
Marilda Pasqual Schneider, Elton Luiz Nardi, Zenilde Durli   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Quels savoirs pour l’enseignement du français dans les plans de formation suisses romands ?

Repères, 2011
Partie d’un projet plus large sur les pratiques de formation a l’enseignement de la production ecrite, cette contribution vise a comprendre les facteurs et contraintes contextuelles influencant les institutions de formation primaire en Suisse romande. Plus particulierement, il s’agit de situer la didactique du francais dans le fonctionnement global de ...
Gagnon, Roxane, Surian, Marc, FAPSE
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mejora continua de la calidad en una unidad médica de valoración de incapacidad temporal

Medicina y Seguridad del Trabajo, 2007
Objetivo: Nuestro objetivo es el diseño de un plan de mejora continua de la calidad en una Unidad Medica de Valoración de Incapacidades (UMVI). Métodos: La metodología utilizada sigue las directrices marcadas por la Consejería de Salud, en cuanto a ...
Esther Álvarez Theurer, Manuel Vaquero Abellán   +1 more
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

LES SCIENCES DE L’INFORMATION DOCUMENTAIRE A L’AUBE DE SES 5O EN RDC : ESSAI D’UN BILAN A L’INSTITUT SUPERIEUR DE STATISTIQUE DE KINSHASA « ISS-KIN » [PDF]

Ziglôbitha
Résumé : L’Institut Supérieur de Statistique de Kinshasa à travers son département de sciences et techniques documentaires est la première école d’enseignement supérieur en Afrique Centrale a formé dans le domaine de l’archivistique, de la ...
Olivier LONGI NZASI
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

De quelques points de vue sur la formation de chercheurs amérindiens au Brésil

Nuevo mundo - Mundos Nuevos, 2017
Cette communication traitera en premier lieu des multiples formats adoptés au Brésil pour la formation de chercheurs amérindiens, en s’interrogeant sur les modes amérindiens de contrôler la recherche, la production et la circulation de connaissances ...
Dominique Tilkin Gallois
doaj   +1 more source