Results 161 to 170 of about 150,481 (338)
Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models
EMBO Reports, 2018 Planar cell polarity (PCP) describes a cell–cell communication process through which individual cells coordinate and align within the plane of a tissue.
Z. Chen +14 more
semanticscholar +1 more source
Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype
Advanced Functional Materials, EarlyView.In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He +10 more
wiley +1 more source
Microtubules provide directional information for core PCP function
eLife, 2014 Planar cell polarity (PCP) signaling controls the polarization of cells within the plane of an epithelium. Two molecular modules composed of Fat(Ft)/Dachsous(Ds)/Four-jointed(Fj) and a ‘PCP-core’ including Frizzled(Fz) and Dishevelled(Dsh) contribute to ...
Maja Matis +4 more
doaj +1 more source
Planar cell polarity pathway in kidney development, function and disease
Nature Reviews Nephrology, 2021 E. Torban, S. Sokol
semanticscholar +1 more source
Journal of Cell Biology, 2018 Most epithelial cells polarize along the axis of the tissue, a feature known as planar cell polarity (PCP). The initiation of PCP requires cell–cell signaling via the noncanonical Wnt/PCP pathway. Additionally, changes in the cytoskeleton both facilitate
S. Kim +6 more
semanticscholar +1 more source
Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges
Advanced Functional Materials, EarlyView.Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley +1 more source
From polarity to pathology: Decoding the role of cell orientation in osteoarthritis
Journal of Orthopaedic TranslationCell polarity refers to the orientation of tissue and organelles within a cell and the direction of its function. It is one of the most critical characteristics of metazoans. The development, growth, and functional tissue distribution are closely related
Xiwei Fan +3 more
doaj +1 more source
Resistive switching in ultra-thin La0.7Sr0.3MnO3 / SrRuO3 superlattices
, 2014 Superlattices may play an important role in next generation electronic and spintronic devices if the key-challenge of the reading and writing data can be solved.
Johan Vanacken +3 more
core +1 more source
Planar cell polarity: two genetic systems use one mechanism to read gradients
Development, 2018 Our aim in this short Primer is to explain the principles of planar cell polarity (PCP) in animal development. The literature in this small field is complex and specialized, but we have extracted a simple and central story from it.
P. Lawrence, J. Casal
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.In this study, we produced HfN‐based nanoparticles via femtosecond laser ablation in acetone. The nanoparticles exhibit a red‐shifted plasmonic resonance in the NIR‐I window, colloidal stability after coating with polyethyleneglycol, and excellent biocompatibility. The photothermal and X‐ray sensitization therapeutic effects were demonstrated for tumor
Julia S. Babkova +15 more
wiley +1 more source