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Planar cell polarity in development and disease [PDF]
Nature Reviews Molecular Cell Biology, 2017 Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by multiple global cues, including gradients of gene expression, gradients of secreted WNT ligands and anisotropic tissue strain.
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Insight into planar cell polarity
Experimental Cell Research, 2014Planar cell polarity or PCP refers to a uniform cellular organization within the plan, typically orthogonal to the apico-basal polarity axis. As such, PCP provides directional cues that control and coordinate the integration of cells in tissues to build a living organism. Although dysfunctions of this fundamental cellular process have been convincingly
Michael, Sebbagh, Jean-Paul, Borg
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Planar cell polarity and vertebrate organogenesis
Seminars in Cell and Developmental Biology, 2006In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell ...
, Courtney Karner
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Cell division orientation and planar cell polarity pathways
Seminars in Cell and Developmental Biology, 2009The orientation of cell division has a crucial role in early embryo body plan specification, axis determination and cell fate diversity generation, as well as in the morphogenesis of tissues and organs. In many instances, cell division orientation is regulated by the planar cell polarity (PCP) pathways: the Wnt/Frizzled non-canonical pathway or the Fat/
Yohanns Bellaiche
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Role of cell polarity and planar cell polarity (PCP) proteins in spermatogenesis
Critical Reviews in Biochemistry and Molecular Biology, 2020Studies on cell polarity proteins and planar cell polarity (PCP) proteins date back to almost 40 years ago in Drosophila and C. elegans when these proteins were shown to be crucial to support apico-basal polarity and also directional alignment of polarity cells across the plane of an epithelium during morphogenesis.
Chris Wong, , Ren-Shan Ge
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Fidelity in planar cell polarity signalling
Nature, 2003The polarity of Drosophila wing hairs displays remarkable fidelity. Each of the approximately 30,000 wing epithelial cells constructs an actin-rich prehair that protrudes from its distal vertex and points distally. The distal location and orientation of the hairs is virtually error free, thus forming a nearly perfect parallel array.
Dali, Ma +4 more
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Biomechanical regulation of planar cell polarity in endothelial cells
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2022Cell polarity refers to the uneven distribution of certain cytoplasmic components in a cell with a spatial order. The planar cell polarity (PCP), the cell aligns perpendicular to the polar plane, in endothelial cells (ECs) has become a research hot spot.
Caihong, Wang +6 more
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The planar cell polarity pathway in vertebrate development
Developmental Dynamics, 2011AbstractDirecting the orientation of cells in three dimensions is a fundamental aspect of many of the processes underlying the generation of the appropriate shape and function of tissues and organs during embryonic development. In an epithelium, this requires not only the establishment of apicobasal polarity, but also cell arrangement in a specific ...
Wansleeben, C., Meijlink, Frits
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Planar Cell Polarity in the Inner Ear
2012The inner ears of vertebrates represent one of the most striking examples of planar cell polarity (PCP). Populations of directionally sensitive mechanosensory hair cells develop actin-based stereociliary bundles that are uniformly oriented. Analysis of perturbations in bundle polarity in mice with mutations in Vangl2 formed the basis for the initial ...
Helen, May-Simera, Matthew W, Kelley
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Frizzled signaling and cell–cell interactions in planar polarity
Current Opinion in Cell Biology, 2001The function of the Frizzled pathway is essential for the formation of the array of distally pointing hairs found on the Drosophila wing. Previous research found that regulating the subcellular location for hair initiation controlled hair polarity.
P N, Adler, H, Lee
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