Results 91 to 100 of about 1,730,522 (288)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ferroelectric Order Evolution in Freestanding PbTiO3 Films Monitored by Optical Second Harmonic Generation

Advanced Science
The demand for low‐dimensional ferroelectric devices is steadily increasing, however, the thick substrates in epitaxial films impede further size miniaturization.
Sisi Huang, Shuai Xu, Cheng Ma, Pengzhan Li, Er‐Jia Guo, Chen Ge, Can Wang, Xiulai Xu, Meng He, Guozhen Yang, Kuijuan Jin   +10 more
doaj   +1 more source

A New Proof for the Description of Holomorphic Flows on Multiply Connected Domains

International Journal of Mathematics and Mathematical Sciences, 2014
We provide a new proof for the description of holomorphic and biholomorphic flows on multiply connected domains in the complex plane. In contrast to the original proof of Heins (1941) we do this by the means of operator theory and by utilizing the ...
F. Jafari, Z. Słodkowski, T. Tonev
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Visualization and manipulation of meta-stable polarization variants in multiferroic materials

AIP Advances, 2013
Here we demonstrate the role of meta-stable polarization variants in out-of-plane polarization switching behavior in epitaxially grown BiFeO3 thin films using angle-resolved piezoresponse force microscopy (AR-PFM). The out-of-plane polarization switching
Moonkyu Park, Kwangsoo No, Seungbum Hong
doaj   +1 more source

Nonlinear automorphisms of plane domains [PDF]

Conformal Geometry and Dynamics of the American Mathematical Society, 1999
We prove that the number of holomorphic nonlinear polynomials mapping a plane domain one-to-one onto itself is at most countable.
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source