Results 111 to 120 of about 1,730,522 (288)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Electronic Journal of Differential Equations, 2003 We consider the singularly perturbed Allen-Cahn equation on a strictly convex plane domain. We show that when the perturbation parameter tends to zero there are solutions having a transition layer that tends to a straight line segment.
Clara E. Garza-Hume, Pablo Padilla
doaj
A stereological metric for plane domains
Advances in Applied Mathematics, 1987 In this paper we consider the chord length distribution \(\omega_ S(t)\) for a plane domain S [see \textit{R. Sulanke}, Math. Nachr. 23, 51-74 (1961; Zbl 0101.404)]. Sulanke has shown that when s is convex \(\omega_ S(t)\) is a continuous function of t, the chord length.
openaire +2 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Dirichlet problem for general A-harmonic equations in simply connected domains
Доповiдi Нацiональної академiї наук УкраїниThe article is devoted to theorems on the existence, representation, and regularity of solutions to the Dirichlet problem with continuous data for general A-harmonic equation div A grad U = 0 in the real plane with matrix valued coefficients A.
В.Я. Гутлянський +3 more
doaj +1 more source
Weierstrass points of plane domains [PDF]
Pacific Journal of Mathematics, 1967 openaire +2 more sources
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source