Results 91 to 100 of about 543,681 (314)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
A Note On Vertex Colorings Of Plane Graphs
Discussiones Mathematicae Graph Theory, 2014 Given an integer valued weighting of all elements of a 2-connected plane graph G with vertex set V , let c(v) denote the sum of the weight of v ∈ V and of the weights of all edges and all faces incident with v.
Fabricia Igor +2 more
doaj +1 more source
Which point sets admit a $k$-angulation?
Journal of Computational Geometry, 2014 For \(k\ge 3\), a \(k\)-angulation is a 2-connected plane graph in which every internal face is a \(k\)-gon. We say that a point set \(P\) admits a plane graph \(G\) if there is a straight-line drawing of \(G\) that maps \(V(G)\) onto \(P\) and has the ...
Michael S. Payne +2 more
doaj +1 more source
Infinitesimal rigidity in normed planes
, 2018 We prove that a graph has an infinitesimally rigid placement in a non-Euclidean normed plane if and only if it contains a $(2,2)$-tight spanning subgraph.
Dewar, Sean
core +1 more source
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
Galois connections between sets of paths and closure operators in simple graphs
Open Mathematics, 2018 For every positive integer n,we introduce and discuss an isotone Galois connection between the sets of paths of lengths n in a simple graph and the closure operators on the (vertex set of the) graph.
Šlapal Josef
doaj +1 more source
On building 4-critical plane and projective plane multiwheels from odd wheels [PDF]
, 2012 We build unbounded classes of plane and projective plane multiwheels that are 4-critical that are received summing odd wheels as edge sums modulo two. These classes can be considered as ascending from single common graph that can be received as edge sum ...
Zeps, Dainis
core +2 more sources
Plane elementary bipartite graphs
Discrete Applied Mathematics, 2000 AbstractA connected graph is called elementary if the union of all perfect matchings forms a connected subgraph. In this paper we mainly study various properties of plane elementary bipartite graphs so that many important results previously obtained for hexagonal systems are treated in a unified way.
Zhang, HP, Zhang, FJ
openaire +3 more sources
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source