We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Contraception, Abortion and Assisted Fertility Among Muslim Women A Look at Islamic Culture and Policy in Iran and Afghanistan [PDF]
Discourse on women\u27s reproductive rights through the lens of Muslim culture. The use of contraception, assisted fertility and abortion, are analyzed in Iran and Afghanistan.
Jacobsen, Hayley
core +1 more source
On The Bureaucrats'Behavior in Public Planning Agency
Existing studies on the bureaucracy have not dealt with organization structure or transmission of information clearly. In this paper we build a model for the Bureaucrats' Behavior on the basisof game theory. We focus on Herd Behavior of bureaucrats which depends on the probability of their ability or transmission of information change, bureaucrats ...
Masami OKADA +2 more
openaire +2 more sources
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Promising Practices: BPA&O Collaboration with One-Stop Centers, Part I. Co-location of One Stop and BPA&O Services: Resource Partnership (Massachusetts) [PDF]
The 1997 Workforce Investment Act reformed the national workforce development system and created One Stop Employment Centers in each state. As part of this reform, state vocational rehabilitation agencies and other employment services are brought ...
Malloy, JoAnne +2 more
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Peranan Bkkbn dalam Pembangunan Kesejahteraan Sosial (suatu Studi di Badan Keluarga Berencana, Pemberdayaan Perempuan dan Perlindungan Anak Kabupaten Minahasa Selatan) [PDF]
In accordance with the duties and functions BKKBN or Regional FamilyPlanning Agency has a strategic role in the development of social welfare . The role willbe realized as expected if the Family Planning Agency may formulate and implementprograms that ...
DENGO, S. (SALMIN) +2 more
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Embodied cognition and temporally extended agency [PDF]
According to radical versions of embodied cognition, human cognition and agency should be explained without the ascription of representational mental states.
Schlosser, Markus
core

