Results 121 to 130 of about 7,913,970 (300)

Morphometric and marker-assisted evaluation of melon (Cucumis melo) segregating population

Discover Plants
Melon is a commercially important crop, yet its adaptation and genetic enhancement, particularly in regions like Bangladesh, remain limited by insufficient comprehensive evaluations of the agronomic performance of diverse global germplasm.
Md Jahid Hasan Jone, Md Nure Adil Siddique, Mehnaj Fatema, Nusrat Jahan Nezu, Upama Mondal, Jobadatun Naher, Mohammad Rashed Hossain   +6 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

From Mendel to genomics, plant breeding milestones: a review [PDF]

, 2002
Plant breeding has evolved from an intuitive strategy of choosing the best plants in the field to an excitingscience of combining genes to improve desirable traits.
Toledo, José Francisco Ferraz de, Guimarães, Elcio Perpétuo, Borém, Aluízio, Federizzi, Luiz Carlos   +3 more
core   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Unlocking the Genetic Blueprint of Erucic Acid Content in Mustard (Brassica napus): A Meta-QTL Exploration

The Scientific World Journal
Brassica napus is a major oilseed crop used for edible oil and industrial applications. Because high-erucic acid (EA) levels reduce oil quality, identifying robust loci controlling EA is a priority for breeding low-EA rapeseed cultivars.
Md. Yeamin Hossain, Md. Ridwanul Islam, Mahfuj Ahmed, Shahanaz Parveen, Kazi Md. Kamrul Huda, Mst. Sufara Akhter Banu, Masashi Inafuku, Md. Harun-Ur-Rashid   +7 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

R&D Appropriability and Planned Obsolescence: Empirical Evidence from Wheat Breeding in the UK (1960-1995) [PDF]

Plant breeders face a unique appropriation problem - plants are reproducible, genetic information is heritable and seeds can be multiplied. The paper uses indicators of varietal age as a proxy for durability to examine strategies of planned obsolescence.
Rangnekar, Dwijen
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Genetic diversity of barley landraces from Near East, North Africa and Southern Europe in relation to resistance to powdery mildew

Plant Protection Science, 2002
This study was conducted to determine the resistance to powdery mildew in 218 barley landraces collected in Near East (Israel, Lebanon, Syria, Turkey, Iran, Iraq), North Africa (Egypt, Algeria, Morocco) and Southern Europe (Greece, Bulgaria, Yugoslavia ...
J.H. Czembor, H.J. Czembor, M. Mackey
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source