Results 141 to 150 of about 525,389 (295)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
The analysis of carbohydrates of the cell wall of plants [PDF]
F. W. Norris, Carl Emil Resch
openalex +1 more source
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen+12 more
wiley +1 more source
In my own time: A non-cell-autonomous circadian regulation in plant cells. [PDF]
Ugalde JM, Maric A.
europepmc +1 more source
VIII.—On the power of the living plant to restrain the evaporation of the cell-sap [PDF]
Hugo von Mohl
openalex +1 more source
Distribution of Boron in Cells of Dicotyledonous Plants in Relation to Growth. [PDF]
J. R. Skok, Wayne J. McIlrath
openalex +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
FACTORS RENDERING THE PLASMOLYTIC METHOD INAPPLICABLE IN THE ESTIMATION OF OSMOTIC VALUES OF PLANT CELLS [PDF]
Elizabeth C. M. Ernest
openalex +1 more source
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma+9 more
wiley +1 more source
Restraining Quiescence Release-Related Ageing in Plant Cells: A Case Study in Carrot. [PDF]
Schulz K+9 more
europepmc +1 more source