Results 81 to 90 of about 556,291 (294)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Differential effect of plant lectins on mast cells of different origins
Brazilian Journal of Medical and Biological Research, 2005 Histamine release induced by plant lectins was studied with emphasis on the carbohydrate specificity, external calcium requirement, metal binding sites, and mast cell heterogeneity and on the importance of antibodies bound to the mast cell membrane to ...
F.C. Lopes +4 more
doaj +1 more source
Utilization of plant cell cultures for production of biochemicals [PDF]
, 2008 Peter E. Brodelius
openalex +1 more source
Pectin self-assembly and its disruption by water: Insights into plant cell wall mechanics [PDF]
, 2021 Jacob John +4 more
openalex +1 more source
Plant Cells as Pharmaceutical Factories
Current Pharmaceutical Design, 2013 Molecules derived from plants make up a sizeable proportion of the drugs currently available on the market. These include a number of secondary metabolite compounds the monetary value of which is very high. New pharmaceuticals often originate in nature.
Häkkinen, Suvi +8 more
openaire +4 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Comparative Investigation of Physiological and Anticancer Properties of Gundelia tournefortii L. From Three Regions of Javanroud, Kermanshah (Iran) on HL-60 Cancer Cells [PDF]
Complementary Medicine Journal of Faculty of Nursing and MidwiferyIntroduction: Cancer is a disease that occurs due to uncontrollable cell division under the influence of genetic and environmental factors. Nowadays, various methods of chemotherapy and radiotherapy are used for treating different types of cancer, but ...
Yosra Sedighi +2 more
doaj
Involvement of plant stem cells or stem cell-like cells in dedifferentiation
Frontiers in Plant Science, 2015 Dedifferentiation is the transformation of cells from a given differentiated state to a less differentiated or stem cell-like state. Stem cell-related genes play important roles in dedifferentiation, which exhibits similar histone modification and DNA ...
Fangwei eJiang +3 more
doaj +1 more source