Results 181 to 190 of about 1,325,312 (300)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Modeling Growth Dynamics of <i>Lemna minor</i>: Process Optimization Considering the Influence of Plant Density and Light Intensity. [PDF]

Plants (Basel)
von Salzen J, Petersen F, Ulbrich A, Streif S.   +3 more
europepmc   +1 more source

Optimized nitrogen rate, plant density, and irrigation level reduced ammonia emission and nitrate leaching on maize farmland in the oasis area of China. [PDF]

PeerJ, 2022
Asibi AE, Yin W, Hu F, Fan Z, Gou Z, Yang H, Guo Y, Chai Q.   +7 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Alleviating Plant Density and Salinity Stress in <i>Moringa oleifera</i> Using Arbuscular Mycorrhizal Fungi: A Review. [PDF]

J Fungi (Basel)
Khoza T, Masenya A, Khanyile N, Thosago S.   +3 more
europepmc   +1 more source

Nitrogen rate and plant density interaction enhances grain yield by regulating the grain distribution of secondary branches on the panicle axis and photosynthesis in japonica rice. [PDF]

Photosynthetica, 2022
Gong YL, Lei Y, Zhang XP, Yan BC, Ju XT, Cheng XY, Zhang JD, Sun XY, Xu H, Chen WF.   +9 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Optimizing pineapple production under waterlogged soil condition in low input management using adequate ridge tillage height and plant density. [PDF]

Front Plant Sci
Etame Kossi GM, Beyegue HD, Boukong A, Ossogo RG, Lidjo L.   +4 more
europepmc   +1 more source

Modeling Maize Canopy Morphology in Response to Increased Plant Density. [PDF]

Front Plant Sci, 2020
He L, Sun W, Chen X, Han L, Li J, Ma Y, Song Y.   +6 more
europepmc   +1 more source