Results 91 to 100 of about 442,874 (256)

Diagnosing plant diseases: what do we ask and why do we ask for it?

, 2017
Diagnosing a plant disease or other injury is like going to a medical doctor who must ask several questions before making an accurate diagnosis and recommending a treatment. If you withhold information, it can lead to a misdiagnosis.
Sparks, Adam H., Sigel, Luise, Adorada, Dante L., Kelly, Lisa   +3 more
core  

Evaluation of non-chemical seed treatment methods for the control of Alternaria dauci and A. radicina on carrot seeds

, 2010
The current study was initiated to evaluate the efficacy of physical methods (hot water, aerated steam, electron treatment) and agents of natural origin (resistance inducers, plant derived products, micro-organisms) as seed treatments of carrots for ...
Kromphardt, C., Schmitt, Annegret,, Schmitt, Annegret, Forsberg, Gustaf, Groot, Steven P. C.,, Schmitt, A., Eckhard Koch, van der Wolf, J.M., Tinivella, Federico,, Wright, Sandra, A. I.,, Jahn, Marga,, Tahsein Amein, Gustaf Forsberg, Wright, S.A.I., Gullino, M.L., van der Wolf, Jan,, Roberts, S.J., Krauthausen, Hermann-Josef, Forsberg, G., Sigrid Werner, Forsberg, Gustaf,, Steven P. C. Groot, Stephan, D., Tinivella, F., Wolf, J.M., van der, Maria L. Gullino, Tinivella, Federico, Amein, T., Amein, Tahsein,, van der Wolf, Jan, Koch, Eckhard, Gullino, Maria L., Koch, Eckhard,, Stephan, Dietrich, Groot, S.P.C., Groot, Steven P. C., Dietrich Stephan, Steven J. Roberts, Kromphardt, Carola, Roberts, Steven J., Hermann-Josef Krauthausen, Gullino, Maria L.,, Werner, Sigrid,, Annegret Schmitt, Sandra A. I. Wright, Stephan, Dietrich,, Werner, S., Roberts, Steven J.,, Krauthausen, H.J., Jan van der Wolf, Wright, Sandra A. I.,, Koch, E., Kromphardt, Carola,, Jahn, Marga, Carola Kromphardt, Krauthausen, Hermann-Josef,, Jahn, M., Marga Jahn, Federico Tinivella, Werner, Sigrid   +59 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Analysis of rhizosphere bacterial communities in Arabidopsis: impact of plant defense signaling

, 2009
In the rhizosphere, numerous microbial and plant-microbe interactions occur. Of special interest is the ability of specific rhizosphere bacteria to elicit induced systemic resistance (ISR), a state of enhanced defensive capacity of the plant that is ...
Sub Plant-Microbe Interactions, Doornbos, R.F., Plant Microbe Interactions   +2 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A Model of Regulatory Burden in Technology Diffusion: The Case of Plant-Derived Vaccines. [PDF]

Plant-derived vaccines may soon displace conventional vaccines. Assuming there are no major technological barriers undermining the feasibility of this innovative technology, it is worthwhile to generate quantitative models of regulatory burden of ...
Bérard, Céline, Gold, Richard, Castle, David, Cloutier, Martin, Kumagai, Kira   +4 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source