Results 161 to 170 of about 1,164,328 (326)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An Analysis of Plant Diseases Identification Based on Deep Learning Methods. [PDF]

Plant Pathol J, 2023
Gong X, Zhang S.
europepmc   +1 more source

Plant Diseases [PDF]

Nature, 1943
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

TrIncNet: a lightweight vision transformer network for identification of plant diseases. [PDF]

Front Plant Sci, 2023
Gole P, Bedi P, Marwaha S, Haque MA, Deb CK.   +4 more
europepmc   +1 more source

Systemic effect of microbial preparations on causative microorganisms of bacterial diseases of tomato plants

, 2016
Yu. V. Kolomiiets, I. Hryhoriuk, Л. Буценко, Liubov Biliavska   +3 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Brevibacillus brevis HNCS-1: a biocontrol bacterium against tea plant diseases. [PDF]

Front Microbiol, 2023
Yang W, Yang H, Bao X, Hussain M, Bao Q, Zeng Z, Xiao C, Zhou L, Qin X.   +8 more
europepmc   +1 more source

Plant diseases in West Virginia in 1928 /

, 1929
W. Andrew Archer, United States.
openalex   +2 more sources

Fatty liver diseases, mechanisms, and potential therapeutic plant medicines

, 2020
Jiazhen Zhu, Hongwei Yi, Wei Huang, Tao Pang, Huiping Zhou, Xudong Wu   +5 more
openalex   +2 more sources