Results 41 to 50 of about 7,534,933 (256)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Phytochemical Analysis, Antioxidant Potential, and Cytotoxicity Evaluation of Traditionally Used Artemisia absinthium L. (Wormwood) Growing in the Central Region of Saudi Arabia

Plants, 2022
Artemisia absinthium, a plant distributed worldwide, has been reported for its numerous traditional uses, and its phytoconstituents have been investigated in several previous publications.
Hamdoon A. Mohammed
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Yield and Composition of the Essential Oil of Basil on Plant Growth Regulators Application

, 2011
This study aimed at evaluating the effect of plant growth regulators on the yield and composition of the essential oil of basil (Ocimum basilicum L.).
Ono, E. O., Rodrigues, J. D. [UNESP], Barreiro, A. P., Marques, M. O. M., Ono, E. O. [UNESP], Barreiro, A. P. [UNESP], Rodrigues, J. D.   +6 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The Effect of Nitrogen and Plant Density on Some Growth Characteristics, Yield and Essential Oil in Peppermint (Mentha piperita L.)

پژوهشهای زراعی ایران, 2011
In order to study the effect of different amounts of nitrogen and plant density on growth, yield, the percentage of essential oil in leaf and essential oil yield of peppermint (Mentha piperita L.), an experiment was conducted in 2008 at the Experimental ...
z Izadi, Gh Ahmadvand, M Esna-Ashari, M Piri   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Effects of plant density, mineral fertilization and effective microorganisms on the development and essential oil yield of Ocimum basilicum L. [PDF]

Archives of Agriculture Sciences Journal
This study examined the impacts of plant density, mineral fertilizers (NPK), biological fertilizers (effective microorganisms, EM), and their interactions on the growth, essential oil content, and chemical composition of sweet basil (Ocimum basilicum L.)
A. Mahmoud, Fatma Fouad
doaj   +1 more source

Some Agronomical Characteristics and Essential Oil Content of Oregano (Origanum onites L.) as Influenced by Planting Densities

, 2009
Oregano (Origanum onites L.) a highly valued medicinal plant, is rich in essential oil. The objective of the experiment was to determine the relative importance of planting densities on yield components and essential oil components of O.
Kizil, Sueleyman, Khawar, Khalid Mahmood, Ipek, Arif, Arslan, Neset, KHAVAR, KHALID MAHMOOD, Kizil, Süleyman   +5 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source