Results 51 to 60 of about 7,534,933 (256)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Chemical Composition, Antioxidant and Anti-bacterial Potential of Essential Oil of Medicinal plant Isodon rugosus

, 2017
Isodon rugosus is a medicinally valuable herb containing a variety of important secondary metabolites and essential oil with important chemical constituents of pharmaceutical precursors. The active components of volatile oil of I.
Tariq, A, Alsaid, MS, Ullah, R (reprint author), King Saud Univ, Coll Pharm, Aromat & Poisonous Plants Res Ctr, Dept Pharmacognosy & Med, POB 2457, Riyadh 11451, Saudi Arabia., Ullah, R, Marwat, GA, Jan, S, Khan, AU, Iftikhar, S, Adnan, M, Hussain, I, Salman, S, Sadique, M   +11 more
core   +1 more source

Yield and essential oil composition of lippia citriodora HBK leaves and flowers in semi-arid conditions

, 2022
Lippia citriodora H.B.K is an herbal species which contains several aroma compounds and the leaves of the plant are utilized as a seasoning for food preparations and flavoring beverages. In this study, the essential oil composition of the L.
Erdem, Enes, Tonçer, Özlem, Karaman, Şengül, Kamçı, Gizem   +3 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Composition of the Essential Oil of Echinophora Tenuifolia L. Ssp Sibthorpiana (Guss.) Tutin From Turkey [PDF]

, 2002
Echinophora tenuifolia L. ssp. sibthorpiana (Guss.) Tutin, a member of the Umbelliferae family, is a typical aromatic plant of central Turkey. The hydrodistilled essential oil of aerial parts of the plant was analyzed by GC and GC/MS.
Akgül, Atilla, Özcan, M., Chalchat, J.C., Akgül, A., Chalchat, J. C.   +4 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Plant Essential Oil with Biological Activity II

Essential oils (EOs) are some of the most important natural products due to their various biological applications. In fact, many EOs explain crucial antimicrobial activities against several phyto-, food, and human diseases; hence, they are considered ...
Paola Zinno, Giulia Ranaldi, Sofia Allegra, Gabriele Lombardi, Alberto Finamore, Barbara Guantario, Giancarlo Fascella, Antonio Raffo and Marianna Roselli, Michele Massimo Mammano   +8 more
core   +1 more source

Composition of the essential oil of Dorystoechas hastata, a monotypic endemic from Turkey

, 1992
GC and GC/MS analysis of the essential oils of leaves, spikes, flowering leafy branches and woody stems of Dorystoechas hastata were conducted. Forty-seven compounds representing 87-98% of the oil were identified. Oil compositions varied according to the
Öztürk, N., Başer, K. Hüsnü Can, K. Hüsnü Can Başer, Öztürk, Nilgün Kavrut, Nilgün Kavrut Öztürk   +4 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Histochemistry, content and chemical composition of essential oil in different organs of Alpinia zerumbet

Ciência Rural, 2013
Alpinia zerumbet is a medicinal plant from Asian origin used in folk medicine for the treatment of hypertension, which effect is attributed to terpinen-4-ol, the major component of the essential oil.
Caroline Nery Jezler, Ricardo Silva Batista, Péricles Barreto Alves, Delmira da Costa Silva, Larissa Corrêa do Bomfim Costa   +4 more
doaj   +1 more source