Results 191 to 200 of about 1,096,200 (391)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

On the biosynthesis and evolution of apocarotenoid plant growth regulators.

Seminars in Cell and Developmental Biology, 2020
Jian You Wang, Pei-Yu Lin, S. Al‐Babili   +2 more
semanticscholar   +1 more source

Effect of plant growth regulators on growth and yield of spinach beat (Beta valgaris var.Begalensis)

verma, Roma, singh, Bineeta
openalex   +1 more source

Effects of plant growth regulators on Orobanche coerulescens seed germination. [PDF]

Bot Stud
Wang YH, Lin KH, Tseng YH, Chen CI, Chen CC, Wang CW, Huang MY.   +6 more
europepmc   +1 more source

Effects of plant growth regulators and sucrose on proliferation and quality of embryogenic tissue in Picea pungens. [PDF]

Sci Rep, 2023
Gao F, Cao X, Qin C, Chen S, Cai J, Sun C, Kong L, Tao J.   +7 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Plant Growth Regulation [PDF]

, 2013
openaire   +1 more source

Plant growth regulators enhance growth and photosynthetic performance in endangered Firmiana Kwangsiensis seedlings. [PDF]

BMC Plant Biol
Ouyang Z, Jia X, Liao H, Xu T, Yang M, Gong L, Xu T, Su Z, Gao X, Yang Q, Zhang L, Su D, Teng W.   +12 more
europepmc   +1 more source

Plant growth regulators affecting canola (Brasica Napus L.) biochemistry including oil yield under drought stress. [PDF]

Physiol Mol Biol Plants, 2023
Hosseini P, Mohsenifar K, Rajaie M, Babaeinejad T.   +3 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source