Results 61 to 70 of about 3,782,024 (253)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5 [PDF]

, 2022
Plant-parasitic nematodes are a major threat to crop production in all agricultural systems. The scarcity of classical resistance genes highlights a pressing need to find new ways to develop nematode-resistant germplasm.
Siddique, Shahid, Maier, Tom, Baum, Thomas, Masonbrink, Rick, et al.   +4 more
core  

Bacterial exopolysaccharides mediate activation of flavin-containing monooxygenase 2 to extend lifespan in Caenorhabditis elegans

Cell Communication and Signaling
The gut microbiota plays a pivotal role in modulating host physiology and longevity through the production of microbial-derived molecules. Among these, bacterial exopolysaccharides (EPS) represent a structurally diverse group of surface polysaccharides ...
Stefan Jakovljević, Dušan Radojević, Svetlana Soković Bajić, Emilija Brdarić, Hristina Mitrović, Jelena Đokić, Linda Baumann, Aleksandra Trifunovic, Nataša Golić, Miroslav Dinić   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Distinct Signatures of Host Defense Suppression by Plant-Feeding Mites [PDF]

, 2018
Tomato plants are attacked by diverse herbivorous arthropods, including by cell-content-feeding mites, such as the extreme generalist Tetranychus urticae and specialists like Tetranychus evansi and Aculops lycopersici.
Schuurink, Robert, Juan M. Alba, Glas, J.J., Bernardus C. J. Schimmel, Kant, Merijn, Nicky Wybouw, Alba, J.M., Wybouw, Nicky, Robert C. Schuurink, Kant, M.R., Schuurink, R.C.; id_orcid, Meijer, T.T., Schimmel, Bernardus C. J., Tomas T. Meijer, Meijer, Tomas, Wybouw, N., Alba, Juan, Merijn R. Kant, Joris J. Glas, Schimmel, B.C.J., Schuurink, R.C., Glas, Joris   +21 more
core   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Corrigendum - Butterfly host plant Monograph

Journal of Threatened Taxa, 2018
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doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Microbial mediation of fruit fly–host plant interactions: is the host plant the "centre of activity"?

, 2002
Insects utilize resources in their environment with the aid of mutualistic or symbiotic mediation by microorganisms. Some insect species such as ants and termites often have complex ecological and evolutionary associations with their symbionts, while the
J. Bradley, Raghu, S., Clarke, Anthony R., A. R. Clarke, S. Raghu, Bradley, Jill   +5 more
core   +1 more source

Membrane Trafficking in Plant Immunity [PDF]

, 2017
Plants employ sophisticated mechanisms to interact with pathogenic as well as beneficial microbes. Of those, membrane trafficking is key in establishing a rapid and precise response.
Zavaliev, Raul, Raul Zavaliev, Xinnian Dong, Dong, Xinnian, Yangnan Gu, Gu, Yangnan   +5 more
core   +1 more source