Results 141 to 150 of about 5,629,257 (381)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Implementation of RGB and Grayscale Images in Plant Leaves Disease Detection - Comparative Study

, 2016
Background/Objectives: Digital image processing is used various fields for analyzing different applications such as medical sciences, biological sciences. Various image types have been used to detect plant diseases. This work is analyzed and compared two
K. Padmavathi, K. Thangadurai
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Color Enrichment to Use of Plant Leaves in Eco Printing "An Applied Study"

الاكاديمي
            The current study is concerned with the color enrichment of plant leaves in environmental printing because of their aesthetic and artistic values that work to achieve the expressive dimension in graphic works.
Ruaa Ali Jebur, Assad Jawad Abdmuslim
doaj   +1 more source

Soil, Water, and Vegetation Conditions in South Texas [PDF]

The author has identified the following significant results. Reflectance differences between the dead leaves of six crops (corn, cotton, sorghum, sugar cane, citrus, and avocado) and the respective bare soils where the dead leaves were lying on the ...
Gausman, H. W., Leamer, R. W., Richardson, A. J., Wiegand, C. L.   +3 more
core   +1 more source

The Environmental Significance Of Stable Carbon Isotope Composition Of Modern Plant Leaves In The Northern Tibetan Plateau, China [PDF]

, 2007
Guangxiu Liu, Ming Li, Lizhe An
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Medicinal plants used to treat TB in Ghana

International Journal of Mycobacteriology, 2015
Aims: The current study was designed to document medicinal plant species that are traditionally used to treat tuberculosis (TB) by Ghanaian communities.
Joseph Mwanzia Nguta, Regina Appiah-Opong, Alexander K Nyarko, Dorothy Yeboah-Manu, Phyllis G.A Addo   +4 more
doaj   +1 more source

Mercury affects the phylloplane fungal community of blueberry leaves to a lesser extent than plant age [PDF]

, 2017
Katalin Malcolm, John Dighton, Tamar Barkay   +2 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source