Results 91 to 100 of about 6,567,069 (395)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Wild Emmer (Triticum turgidum ssp. dicoccoides) Diversity in Southern Turkey: Evaluation of SSR and Morphological Variations

Life
Wild emmer wheat (Triticum turgidum ssp. dicoccoides) is the ancestral species of cultivated tetraploid wheat with BBAA genomes. Because of its full interfertility with domesticated emmer wheat, this wild species can serve as one of the most important ...
Esra Çakır, Ahmad Alsaleh, Harun Bektas, Hakan Özkan   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Morphological classification of plant cell deaths [PDF]

Cell Death & Differentiation, 2011
Programmed cell death (PCD) is an integral part of plant development and of responses to abiotic stress or pathogens. Although the morphology of plant PCD is, in some cases, well characterised and molecular mechanisms controlling plant PCD are beginning to emerge, there is still confusion about the classification of PCD in plants.
van Doorn, W G, Beers, E P, Dangl, J L, Franklin-Tong, V E, Gallois, P, Hara-Nishimura, I, Jones, A M, Kawai-Yamada, M, Lam, E, Mundy, J, Mur, L A J, Petersen, M, Smertenko, A, Taliansky, M, Van Breusegem, F, Wolpert, T, Woltering, E, Zhivotovsky, B, Bozhkov, P V   +18 more
openaire   +4 more sources

Morphological diversity of Meloidogyne spp. from carrot (Daucus carota subsp. Sativus) in Vietnam [PDF]

, 2019
Carrot (Daucus carota subsp. Sativus) is known as one of the most widely cultivated and widely consumed vegetables in the world due to its nutritional and economic values.
Le, Thi Mai Linh, Nguyen, Huu Tien, Nguyen, Thi Duyen, Nobleza, Neriza, Trinh, Quang Phap   +4 more
core  

Phytogenic mounds (nebkhas): effect of Tricomaria usillo on sand entrapment in central-west of Argentina [PDF]

, 2016
Nebkhas, developed by the trapping of sand within the body of a plant, were studied in the Médanos Grandes system, arid central Argentina, during the springs of 2009-2010.In this system, formed by megadunes and overlapping dunes, nebkhas dynamism was ...
Martinez Carretero, Eduardo Enrique, Pastrán, Graciela   +1 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Characterization of the Effect of Increased Plant Density on Canopy Morphology and Stalk Lodging Risk

Frontiers in Plant Science, 2018
Plants react to the environment and to management interventions by undergoing architectural and structural modifications. A field trial was conducted in China in 2016 to study the effects of the plant population on morphological development of the maize ...
A. Sher, Aaqil Khan, U. Ashraf, Hui Liu, J. Li   +4 more
semanticscholar   +1 more source

Epidemics in Networks of Spatially Correlated Three-dimensional Root Branching Structures

, 2011
Using digitized images of the three-dimensional, branching structures for root systems of bean seedlings, together with analytical and numerical methods that map a common 'SIR' epidemiological model onto the bond percolation problem, we show how the ...
C. A. Gilligan, Diekmann O., F. J. Pérez-Reche, F. M. Neri, Gilligan C. A., Hornby D., Jackson M., Keeling M. J., L. da F. Costa, M. Miazaki, Murray J. D., Pastor-Satorras R., S. N. Taraskin, Stauffer D., T. P. Handford   +14 more
core   +2 more sources