Results 91 to 100 of about 412,560 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Post-Harvest Disease Control Using Bacteriophages: Current Strategies, Practical Applications, and Future Trends

Agriculture
Post-harvest bacterial infections pose a serious threat to modern agriculture, resulting in substantial financial losses and environmental issues. Every year, microbial spoiling causes a significant loss in fruit and vegetable production, and traditional
Anna Hoffmann, Katarzyna Sadowska, Weronika Zenelt, Krzysztof Krawczyk   +3 more
doaj   +1 more source

The Arabidopsis NADPH oxidases RbohD and RbohF display differential expression patterns and contributions during plant immunity [PDF]

, 2016
Plant NADPH oxidases, also known as respiratory burst oxidase homologues (RBOHs), produce reactive oxygen species (ROS) that perform a wide range of functions.
Antonio Molina, Berrocal-Lobo, Cyril Zipfel, Jefferson, Jorge Morales, Miguel-Angel Torres, Yasuhiro Kadota   +6 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Bacteriophages as a Sustainable Tool for Plant Disease Management: Benefits and Challenges

Agronomy
Bacterial diseases cause significant economic losses and pose a major challenge to global crop yields. These diseases reduce yields and affect food security, particularly for small-scale farmers in developing regions.
Anna Hoffmann, Katarzyna Sadowska, Weronika Zenelt, Krzysztof Krawczyk   +3 more
doaj   +1 more source

2,4-D and Mycoleptodiscus terrestris for control of Eurasian Watermilfoil [PDF]

, 2005
Growth chamber studies were conducted to evaluate the impact of an indigenous fungal pathogen, Mycoleptodiscus terrestris (Gerd.) Ostazeski, and the herbicide 2,4-D applied alone and in combination with one another, on the growth of a nuisance ...
Nelson, Linda S., Shearer, J. F.
core  

Fungal Pathogens Infecting Soybean Aphid and Aphids on Other Crops Grown in Soybean Production Areas of Michigan [PDF]

, 2018
Seasonal prevalence of fungal pathogens infecting soybean aphid, Aphis glycines Matsumura (Hemiptera: Aphididae), was assessed from 2004 to 2006 in two Michigan soybean production areas. In 2005 and 2006 field-collected soybean aphids were incubated, and
Brewer, Michael J, Noma, Takuji
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source