Results 91 to 100 of about 2,928,987 (306)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A Covert Operation by a Plant Pathogen [PDF]
Cell Host & Microbe, 2016 Phytopathogens have mastered the ability to evade plant innate immunity. In this issue of Cell Host & Microbe, Zhou and colleagues (Li et al., 2016) uncover a strategy whereby a bacterial pathogen disables the plant immune system with such precision as to avoid triggering alarms that could potentially reveal its presence.
Jeff H, Chang, Javier F, Tabima
openaire +2 more sources
Molecular Plant-Microbe Interactions, 2000 The phytopathogenic bacterium Erwinia chrysanthemi produces five major pectate lyases that are key virulence factors in soft-rot disease development. Using transcriptional fusions, we studied the regulation of pelA, pelD, and pelE gene expression as a ...
Laurence Nachin, Frédéric Barras
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Investigating the Pea Virome in Germany—Old Friends and New Players in the Field(s)
Frontiers in Microbiology, 2020 Peas are an important legume for human and animal consumption and are also being used as green manure or intermediate crops to sustain and improve soil condition. Pea production faces constraints from fungal, bacterial, and viral diseases.
Yahya Z. A. Gaafar +8 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
PhytoFrontiersHigh-throughput sequencing (HTS) has been demonstrated to be a paradigm shift for post-entry quarantine programs by increasing their ability to detect unknown plant viruses that have remained undetected by conventional diagnostic tools.
Peter Abrahamian +13 more
doaj +1 more source
Scientific Reports, 2023 Human Puumala virus (PUUV) infections in Germany fluctuate multi-annually, following fluctuations of the bank vole population size. We applied a transformation to the annual incidence values and established a heuristic method to develop a straightforward
Orestis Kazasidis, Jens Jacob
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
PhytoFrontiersErwinia pyrifoliae causes blight symptoms on pears (Pyrus spp.), apple (Malus spp.), and strawberry (Fragaria × ananassa), with up to 40% losses in strawberry observed during a 2013 outbreak in the Netherlands.
Jarred Yasuhara-Bell +2 more
doaj +1 more source