Results 171 to 180 of about 501,563 (307)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Genomic factors limiting the diversity of Saccharomycotina plant pathogens. [PDF]

open access: yesG3 (Bethesda)
Lee S   +10 more
europepmc   +1 more source

Fresh produce as a potential vector for bacterial human pathogens [PDF]

open access: yes, 2009
Hamilton   +8 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento   +3 more
wiley   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak   +4 more
wiley   +1 more source

Plant pathogens affecting the establishment of plant-symbiont interaction

open access: yesFrontiers in Plant Science, 2016
Eduardo Martins de Souza   +2 more
doaj   +1 more source

Foliar-applied double-stranded RNA is mobile, transfers to plant pathogens, and triggers RNAi. [PDF]

open access: yesNucleic Acids Res
Brosnan CA   +7 more
europepmc   +1 more source

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