Results 41 to 50 of about 29,509 (216)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Convergence of developmental mutants into a single tomato model system: 'Micro-Tom' as an effective toolkit for plant development research

Plant Methods, 2011
Background The tomato (Solanum lycopersicum L.) plant is both an economically important food crop and an ideal dicot model to investigate various physiological phenomena not possible in Arabidopsis thaliana. Due to the great diversity of tomato cultivars
Lima Joni E, Zsögön Agustin, Crestana Simone L, Pino Lilian E, Campos Marcelo L, Carvalho Rogério F, Benedito Vagner A, Peres Lázaro EP   +7 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Factors affecting the production of sugarcane yield and sucrose accumulation: suggested potential biological solutions

Frontiers in Plant Science
Environmental stresses are the main constraints on agricultural productivity and food security worldwide. This issue is worsened by abrupt and severe changes in global climate.
Faisal Mehdi, Faisal Mehdi, Zhengying Cao, Zhengying Cao, Shuzhen Zhang, Shuzhen Zhang, Yimei Gan, Yimei Gan, Wenwei Cai, Wenwei Cai, Lishun Peng, Lishun Peng, Yuanli Wu, Yuanli Wu, Wenzhi Wang, Wenzhi Wang, Benpeng Yang, Benpeng Yang   +17 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Edmund frémy

Revista CENIC Ciencias Químicas, 2013
Edmund Frémy (1814-1894) carried extensive research in inorganic and organic chemistry; he characterized ferric, stannic, antimony, and osmium acids; synthesized artificial rubies and colored glasses; prepared a large number of fluorides, isolated ...
Jaime Wisniak
doaj  

The Effects of Climate Changes on the Phenology of Some Chokeberry (Aronia melanocarpa) Cultivars

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Horticulture
Climate change represents a significant challenge characterized by long-term increases in global temperatures, which subsequently alter plant phenology and growth cycles.
Anca Maria CHIOREAN, Zsolt JAKAB- ILYEFALVI, Smaranda ROŞU-MAREŞ, Georgeta GUZU, Claudiu MOLDOVAN, Ioan ZAGRAI, Adrian ASĂNICĂ, Mirela Irina CORDEA   +7 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

A Remote Strawberry Health Monitoring System Performed with Multiple Sensors Approach

Agriculture
Temperature is a key physiological indicator of plant health, influenced by factors including water status, disease and developmental stage. Monitoring changes in multiple factors is helpful for early diagnosis of plant growth.
Xiao Du, Jun Steed Huang, Qian Shi, Tongge Li, Yanfei Wang, Haodong Liu, Zhaoyuan Zhang, Ni Yu, Ning Yang   +8 more
doaj   +1 more source