Results 41 to 50 of about 29,856 (265)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Ecosystem functioning and plant-soil interactions in forests [PDF]
, 2006 The aim of this thesis was to investigate the role of resources in driving ecosystem processes and in influencing soil- and plant communities in boreal and temperate forests, through four complementary experimental studies.
Dehlin, Helena
core
Developmental Control and Plasticity of Fruit and Seed Dimorphism in Aethionema arabicum
, 2016 Understanding how plants cope with changing habitats is a timely and important topic in plant research. Phenotypic plasticity describes the capability of a genotype to produce different phenotypes when exposed to different environmental conditions.
Lenser, Teresa and Graeber, Kai and Cevik, Ozge Selin and Adiguzel, Nezaket and Donmez, Ali A. and Grosche, Christopher and Kettermann, Marcel and Mayland-Quellhorst, Sara and Merai, Zsuzsanna and Mohammadin, Setareh and Thu-Phuong Nguyen and Rumpler, Florian and Schulze, Christina and Sperber, Katja and Steinbrecher, Tina and Wiegand, Nils and Strnad, Miroslav and Scheid, Ortrun Mittelsten and Rensing, Stefan A. and Schranz, Michael Eric and Theissen, Guenter and Mummenhoff, Klaus and Leubner-Metzger, Gerhard
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FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Life, 2023 A plant, being a sessile organism, needs to modulate biochemical, physiological, and molecular responses to the environment in a quick and efficient manner to be protected.
Suresh Kumar +2 more
doaj +1 more source
Abiotic Stress Alleviation with Brassinosteroids in Plant Roots
, 2021 This chapter covers the advances in establishment and optimization of brassinosteroids (BRs) in the alleviation of abiotic stresses such as water, salinity, temperature, and heavy metals in plant system, especially roots.
Marakli, Sevgi, Gozukirmizi, Nermin
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