Results 61 to 70 of about 29,509 (216)

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Applicability of metabolomics to improve sustainable grapevine production

Frontiers in Molecular Biosciences
Metabolites represent the end product of gene expression, protein interaction and other regulatory mechanisms. The metabolome reflects a biological system’s response to genetic and environmental changes, providing a more accurate description of plants ...
Catarina Estêvão, Lénia Rodrigues, Ana Elisa Rato, Raquel Garcia, Hélia Cardoso, Catarina Campos   +5 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Silicon nanoparticles vs trace elements toxicity: Modus operandi and its omics bases

Frontiers in Plant Science
Phytotoxicity of trace elements (commonly misunderstood as ‘heavy metals’) includes impairment of functional groups of enzymes, photo-assembly, redox homeostasis, and nutrient status in higher plants.
Mohammad Mukarram, Mohammad Mukarram, Bilal Ahmad, Sadaf Choudhary, Alena Sliacka Konôpková, Alena Sliacka Konôpková, Daniel Kurjak, Daniel Kurjak, M. Masroor A. Khan, Alexander Lux, Alexander Lux   +10 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Activación del crecimiento de Plantulas de sietecueros (Tibouchin lepidota) por Fitohormonas

Acta Biológica Colombiana, 1996
Many tropical tree species when seedling have a slow growing period that seems to be controlled by a physiological mechanism of hormonal regulation. In "sietecueros" (Tibouchina lepidota (Bnpl.) Baill), different plant hormones like polyamines, auxines ...
Hernán Mauricio Romero Angulo, Jesús Antonio Norato Rodríguez, Margarita María Rojas Gutierrez   +2 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Thermal stress triggers broad Pocillopora damicornis transcriptomic remodeling, while Vibrio coralliilyticus infection induces a more targeted immuno-suppression response.

PLoS ONE, 2014
Global change and its associated temperature increase has directly or indirectly changed the distributions of hosts and pathogens, and has affected host immunity, pathogen virulence and growth rates.
Jeremie Vidal-Dupiol, Nolwenn M Dheilly, Rodolfo Rondon, Christoph Grunau, Céline Cosseau, Kristina M Smith, Michael Freitag, Mehdi Adjeroud, Guillaume Mitta   +8 more
doaj   +1 more source