Results 101 to 110 of about 332,246 (298)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Bekämpfung von Fusarien mit antifungalen Pflanzenprodukten und deren Effekte auf den Mykotoxin-Gehalt von Weizen [PDF]

open access: yes, 2009
Fusarium graminearum (FG) is the most prevalent Fusarium Head Blight (FHB) fungus in Switzerland. In conventional agriculture, fungicides are used to reduce the risk of FHB infection and mycotoxin contamination of wheat.
Forrer, Dr. Hans-Rudolf   +5 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

First experiences in the application of biopreparations against the cherry fruit fly in Southern Russia in 2007 [PDF]

open access: yes, 2008
On the Russian market there are no currently registered biological preparations for the control of Rhagoletis cerasi (cherry fruit fly, CFF), and therefore the effects of natural products against this pest were studied.
Hummel, E., Vasilyeva, L. A.
core  

The Effect of Post-Emergence Application of Biostimulants and Soil Amendments in Maize Cultivation on the Growth and Yield of Plants

open access: yesPlants
Maize is considered to be one of the most significant crops in the world. On a global scale, the appropriate yield level of food can largely affect food security.
Łukasz Sobiech   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Use of Desulfovibrio and Escherichia coli Pd-nanocatalysts in reduction of Cr(VI) and hydrogenolytic dehalogenation of polychlorinated biphenyls and used transformer oil [PDF]

open access: yes, 2012
BACKGROUND Desulfovibrio spp. biofabricate metallic nanoparticles (e.g. ‘Bio-Pd’) which catalyse the reduction of Cr(VI) to Cr(III) and dehalogenate polychlorinated biphenyls (PCBs). Desulfovibrio spp.
Baxter-Plant, VS   +7 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

The Surprising History and Geography of the First "Organic Farming" Association [PDF]

open access: yes, 2008
Readers of narratives of the history of organic farming in Australia will be familiar with such accounts beginning in the "1980s". In questing after the earliest organic farming society, and more particularly in pursuing the spread of the "organic" meme
Paull, John
core  

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