Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Identifying and improving the fibre-degrading activity of rumen microbe-derived fibrolytic bacteria : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, Manawatū, New Zealand [PDF]
, 2017 The dairy industry is extremely important to the New Zealand (NZ) economy, and it accounts for approximately $16.6 billion in exports each year. In NZ, traditional feedstock for cattle, such as grass and hay, consists of cellulose-based fibrous material ...
Atua, Renée Mary Louise
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Characterization of PSII-LHCII supercomplexes isolated from pea thylakoid membranes by one-step treatment with α- and β- dodecyl-D-maltoside [PDF]
, 2012 Adir N. +9 more
core +1 more source
Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts [PDF]
, 2008 Objectives: To evaluate concentration-dependent effects of total extract of Rusta graveolens and its purified alkaloid fraction on the nodal basic and functional properties.
Golalipour, M.J. +4 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Herbal plants and plant preparations as remedial approach for viral diseases. [PDF]
Virusdisease, 2015 Ganjhu RK +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The Preparation of Plant Nucleic Acids [PDF]
Biochemical Journal, 1917 G, Clarke, S B, Schryver
openaire +2 more sources