Results 241 to 250 of about 6,264,471 (313)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Relationship Between Regulatory Frameworks for Protein Content Claims for Plant Protein Foods and the Nutrient Intakes of Canadian Adults. [PDF]

Nutrients
Back S, Marinangeli CPF, Rossi A, Elfaki L, Ahmed M, Chen V, Yang S, Zurbau A, Duncan AM, L'Abbe MR, Kendall CWC, Sievenpiper JL, Chiavaroli L.   +12 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

A comprehensive review on plant protein-based food packaging: Beyond petroleum-based polymers. [PDF]

Curr Res Food Sci
Pawde SV, Kaewprachu P, Kingwascharapong P, Sai-Ut S, Karbowiak T, Jung YH, Rawdkuen S.   +6 more
europepmc   +1 more source

Overexpression of the heavy metal-associated isoprenylated plant protein gene <i>IbHIPP7</i> reduces cadmium accumulation and alleviates cadmium toxicity in sweetpotato. [PDF]

Hortic Res
Dong P, Yin Y, Zhang S, Fan Y, Zhang X, Zhang M, Xia Y, Chen C, Shi L, Chen Y.   +9 more
europepmc   +1 more source

Complementary plant protein pairing does not further increase postexercise myofibrillar protein synthesis after a 20 g protein dose within a high-carbohydrate whole-food matrix in young adults: a randomized controlled trial. [PDF]

Am J Clin Nutr
Zupančič Ž, Barnes TM, Deutz MT, Irwin GL, Zimring JE, Chen C, Askow AT, Ulanov AV, Willard JW, van Loon LJ, Burd NA.   +10 more
europepmc   +1 more source

Dynamic Changes in Amino Acid Release Patterns of Different Plant Protein Sources During In Vitro Digestion and Their Nutritional Value Assessment. [PDF]

Animals (Basel)
Fan Y, Kou Z, Cao J, Wang Z, Zhang T, Han R, Che D.   +6 more
europepmc   +1 more source

Proportional, but not absolute, intake of appropriate plant protein is associated with a reduced risk of chronic kidney disease: a cross-sectional study based on NHANES 2005-2018. [PDF]

Transl Androl Urol
Xia Z, Xiong Y.
europepmc   +1 more source