Results 21 to 30 of about 6,264,471 (313)
Protein & Cell, 2016 Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid plaque pathogenesis in Alzheimer’s disease (AD). Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein ...
Jintao Bao +13 more
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Using comprehensive machine‐learning models to classify complex morphological characters
Ecology and Evolution, 2021 Recognizing and classifying multiple morphological features, such as patterns, sizes, and textures, can provide a comprehensive understanding of their variability and phenotypic evolution.
Dequn Teng, Fengyuan Li, Wei Zhang
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Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
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Frontiers in Neuroscience, 2022 Deficits in responding to joint attention (RJA) are early symptoms of autism spectrum disorder (ASD). Currently, no automated tools exist for identifying and quantifying RJA behaviors.
Jie Zhang +8 more
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Analysing Novel Structures of Protein Complexes Requiring the Central Plant Immune Regulator EDS1 [PDF]
, 2013 Plants as sessile organisms are constantly attacked by pathogens and have evolved a complex immune system to cope with this challenge. The first inducible layer of plant immunity recognises pathogens outside each plant cell and activates a resistance ...
Wagner, Stephan
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Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase
Nature Communications, 2017 Ethylene is a plant hormone that promotes fruit ripening. Here, the authors identify pyrazinamide, a drug used to treat tuberculosis, as an inhibitor of ethylene biosynthesis inArabidopsis thalianaand present the crystal structure of its active form ...
Xiangzhong Sun +10 more
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Communications Biology, 2021 Çoruh, Frank et al. report the structure of monomeric Photosystem I from cyanobacteria Thermosynechoccocus elongatus BP-1. They assign monomerization-induced loss of red chlorophylls to a cluster of chlorophylls adjacent to PsaX.
Orkun Çoruh +9 more
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Plants, 2023 The circadian clock, an endogenous timing system, exists in nearly all organisms on Earth. The plant circadian clock has been found to be intricately linked with various essential biological activities. Extensive studies of the plant circadian clock have
Xingwei Wang, Yanfei Hu, Wei Wang
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Modulation of nitrosative stress by S-nitrosoglutathione reductase is critical for thermotolerance and plant growth in arabidopsis [PDF]
, 2008 Nitric oxide (NO) is a key signaling molecule in plants. This analysis of Arabidopsis thaliana HOT5 (sensitive to hot temperatures), which is required for thermotolerance, uncovers a role of NO in thermotolerance and plant development.
Feelisch, Martin +7 more
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53BP1 and BRCA1 control pathway choice for stalled replication restart
eLife, 2017 The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated remain unclear.
Yixi Xu +7 more
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