Tissue-specific 5-hydroxymethylcytosine landscape of the human genome
Nature Communications, 2021 Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-
Bo He +11 more
doaj +1 more source
Sources of dietary protein and risk of hypertension in a general Dutch population [PDF]
, 2012 Evidence suggests a small beneficial effect of dietary protein on blood pressure (BP), especially for plant protein. We examined the relationship between several types of dietary protein (total, plant, animal, dairy, meat and grain) and the risk of ...
Altorf-van der Kuil, W. +4 more
core +2 more sources
Quantitative tandem affinity purification, an effective tool to investigate protein complex composition in plant hormone signaling : strigolactones in the spotlight [PDF]
, 2018 Phytohormones tightly regulate plant growth by integrating changing environmental and developmental cues. Although the key players have been identified in many plant hormonal pathways, the molecular mechanisms and mode of action of perception and ...
Boyer, François-Didier +8 more
core +2 more sources
Exploring the plant transcriptome through phylogenetic profiling [PDF]
, 2005 Publicly available protein sequences represent only a small fraction of the full catalog of genes encoded by the genomes of different plants, such as green algae, mosses, gymnosperms, and angiosperms. By contrast, an enormous amount of expressed sequence
Vandepoele, Klaas, Van de Peer, Yves
core +1 more source
mBio, 2017 Understanding how bacteria coordinate growth with cell cycle events to maintain cell size homeostasis remains a grand challenge in biology. The period of chromosome replication (C period) is a key stage in the bacterial cell cycle. However, the mechanism
Manlu Zhu +6 more
doaj +1 more source
Effects of organic plant oils and role of oxidation on nutrient utilization in juvenile rainbow trout (Oncorhynchus mykiss) [PDF]
, 2012 The study compared the effect of four either fresh or force oxidized organic plant oils in diets for juvenile rainbow trout (Oncorhynchus mykiss) in which 47% of conventional LT fish meal protein was substituted by a mixture of 3 organic plant protein ...
A. Jokumsen +37 more
core +1 more source
An OB-fold complex controls the repair pathways for DNA double-strand breaks
Nature Communications, 2018 How repair pathway selection occurs is still a matter of debate and many factors have been associated to this function. Here the authors provide insight into the role of FAM35A and C20ORF196, two REV7-interacting proteins, which are recruited at double ...
Shengxian Gao +10 more
doaj +1 more source
Protein-Protein Interactions in Plants [PDF]
Plant and Cell Physiology, 2012 The study of protein-protein interactions (PPIs) is essential to uncover unknown functions of proteins at the molecular level and to gain insight into complex cellular networks. Affinity purification and mass spectrometry (AP-MS), yeast two-hybrid, imaging approaches and numerous diverse databases have been developed as strategies to analyze PPIs.
openaire +2 more sources
Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
Nature Communications, 2017 Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.
Yuan Zhang +7 more
doaj +1 more source
Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M
Nature Communications, 2023 Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to facilitate P. falciparum clearance.
Chenggong Ji +6 more
doaj +1 more source