Results 1 to 10 of about 639,733 (219)
Two types of cyanobacterial phycobilisomes (PBS) are present: the hemidiscoidal PBS (CpcG-PBS) and the membrane-bound PBS (CpcL-PBS). Both types of PBS have ferredoxin:NADP+ oxidoreductase (FNR) attached to the termini of their rods through a CpcD domain.
Xiying Li +8 more
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m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome
m6Am is a dynamic and reversible RNA modification found on the mRNA cap. Here the authors report m6Am-seq to directly distinguish m6Am from m6A and identify functional methylation sites.
Hanxiao Sun +6 more
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Abnormal high temperature (HT) caused by global warming threatens plant survival and food security, but the effects of HT on plant organ identity are elusive.
Jingqiu Lan +6 more
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RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity
The 53BP1-RIF1 pathway is important for DNA repair. Here, the authors identified the histone chaperone ASF1, which functions as a suppressor of DNA end resection through changing high-order chromatin structure, as a partner of RIF1.
Sumin Feng +12 more
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Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
Upstream open reading frames (uORFs) have widespread regulatory functions in eukaryotes, their genomic distribution and evolution is understudied. Here, the authors characterise ~17 million putative uORFs across 478 eukaryotic species, showing how ...
Hong Zhang +5 more
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Author Correction: Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22435 ...
Hong Zhang +5 more
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Tissue-specific 5-hydroxymethylcytosine landscape of the human genome
Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-
Bo He +11 more
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Understanding how bacteria coordinate growth with cell cycle events to maintain cell size homeostasis remains a grand challenge in biology. The period of chromosome replication (C period) is a key stage in the bacterial cell cycle. However, the mechanism
Manlu Zhu +6 more
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An OB-fold complex controls the repair pathways for DNA double-strand breaks
How repair pathway selection occurs is still a matter of debate and many factors have been associated to this function. Here the authors provide insight into the role of FAM35A and C20ORF196, two REV7-interacting proteins, which are recruited at double ...
Shengxian Gao +10 more
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Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.
Yuan Zhang +7 more
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