Results 61 to 70 of about 1,383,408 (312)

CD5L associates with IgM via the J chain

Nature Communications
CD5 antigen-like (CD5L), also known as Spα or AIM (Apoptosis inhibitor of macrophage), emerges as an integral component of serum immunoglobulin M (IgM). However, the molecular mechanism underlying the interaction between IgM and CD5L has remained elusive.
Yuxin Wang, Chen Su, Chenggong Ji, Junyu Xiao   +3 more
doaj   +1 more source

Geminivirus C2 protein represses genes involved in sulphur assimilation and this effect can be counteracted by jasmonate treatment [PDF]

, 2012
Geminiviruses are plant viruses that infect a broad range of crops and cause extensive losses worldwide, having an important economic impact. C2, a multifunctional pathogenicity factor encoded by geminiviruses, has been recently shown to suppress the ...
Balzergue, Sandrine, Bejarano, Eduardo R., García Domínguez, Irene, Huguet, Stéphanie, Lozano Durán, Rosa, Romero González, Luis Carlos   +5 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Architecture and activation of human muscle phosphorylase kinase

Nature Communications
The study of phosphorylase kinase (PhK)-regulated glycogen metabolism has contributed to the fundamental understanding of protein phosphorylation; however, the molecular mechanism of PhK remains poorly understood. Here we present the high-resolution cryo-
Xiaoke Yang, Mingqi Zhu, Xue Lu, Yuxin Wang, Junyu Xiao   +4 more
doaj   +1 more source

The Receptor-Like Kinase SERK3/BAK1 Is Required for Basal Resistance against the Late Blight Pathogen Phytophthora infestans in Nicotiana benthamiana [PDF]

, 2015
BACKGROUND The filamentous oomycete plant pathogen Phytophthora infestans causes late blight, an economically important disease, on members of the nightshade family (Solanaceae), such as the crop plants potato and tomato.
Chaparro-Garcia, Angela, Coffey, Michael D., Findlay, Kim, Gimenez-Ibanez, Selena, Kamoun, Sophien, Rathjen, John P., Schornack, Sebastian, Wilkinson, Rachael C., Zipfel, Cyril   +8 more
core   +1 more source

Protein import into plant mitochondria [PDF]

Plant Molecular Biology, 1997
The presence of plastids in plant cells requires a higher level of precursor recognition by the mitochondrial protein import apparatus than in nonplant organisms. Although the plant presequences display the overall features observed in yeast and mammals, they are generally longer and more hydrophilic.
J, Whelan, E, Glaser
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Genome-wide Mapping of Cellular Protein–RNA Interactions Enabled by Chemical Crosslinking

Genomics, Proteomics & Bioinformatics, 2014
RNA–protein interactions influence many biological processes. Identifying the binding sites of RNA-binding proteins (RBPs) remains one of the most fundamental and important challenges to the studies of such interactions.
Xiaoyu Li, Jinghui Song, Chengqi Yi
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

GRP-3 and KAPP, encoding interactors of WAK1, negatively affect defense responses induced by oligogalacturonides and local response to wounding [PDF]

, 2016
Conserved microbe-associated molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs) act as danger signals to activate the plant immune response.
CERVONE, Felice, DE LORENZO, Giulia, GRAMEGNA, GIOVANNA, MODESTI, VANESSA, SAVATIN, DANIEL VALENTIN, SICILIA, Francesca   +5 more
core   +1 more source