Results 141 to 150 of about 360,443 (313)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

How will plant science contribute to improve productivity in agriculture?—Future prospects of plant science—

Breeding Research, 2019
Akira Isogai, Nobuhiro Tsutsumi, Tadao Asami, Motoaki Seki, Yusuke Saijo, Ken Naito, Kiwamu Minamisawa   +6 more
openaire   +2 more sources

Marketing Efficiency of Dairy Products for Co-operative and Private Dairy Plants in Tamil Nadu - A Comparative Analysis

The marketing of milk and milk products by dairy plants of co-operative and private sectors in Tamil Nadu has been compared. The study is based on the data collected for toned milk, standardized milk, full cream milk, flavoured milk, butter and ghee from
Dhaka, J.P., Rangasamy, N.
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana

, 2008
Background Plant primary carbohydrate metabolism is complex and flexible, and is regulated at many levels. Changes of transcript levels do not always lead to changes in enzyme activities, and these do not always affect metabolite levels and fluxes.
Fu, Jingyuan, Vreugdenhil, Dick, Fu, Jingyuan; id_orcid, Keurentjes, Joost Jb, Keurentjes, J. J. B., Steinhauser, Marie-Caroline, Koornneef, Maarten, Koornneef, M., Steinhauser, M. C., Steinhauser, M., Steinhauser, C., Keurentjes, Joost J. B., Keurentjes, J., Gibon, Y., Keurentjes, J.J.B., Sulpice, R., Gibon, Yves, Stitt, M., Steinhauser, M.C., Sulpice, Ronan, Vreugdenhil, D., Fu, J. Y., Fu, J., Stitt, Mark   +23 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Human Pathogenic Microorganisms in Fresh Produce Production: Lessons Learned When Plant Science Meets Food Safety

Journal of Food Protection
To enhance control of human pathogenic microorganisms in plant production systems, an EU COST Action (HUPLANTcontrol CA16110) was initiated, bringing together microbiologists in food, environmental and plant microbial ecology. This article summarizes the outcomes of multiple workshops and the four main lessons learned: (i) many terminologies need ...
Zhao, Xingchen, Van Overbeek, Leo, Burgess, Catherine M., Holden, Nicola, Brennan, Fiona, Johannessen, Gro S., Allende, Ana, Höfte, Monica, Cottyn, Bart, Pothier, Joel F., Schikora, Adam, Uyttendaele, Mieke   +11 more
openaire   +4 more sources

Endophytic Microorganisms in Tomato Roots, Changes in the Structure and Function of the Community at Different Growing Stages

Microorganisms
This study analyzed flower bud differentiation and fruiting stages to investigate how the structure of the plant endophytic microbial community in the roots of tomatoes changes with plant senescence.
Yufei Wei, Siyu Chen, Xinyan Zhou, Diancao Ding, Jingjing Song, Shangdong Yang   +5 more
doaj   +1 more source

Dissecting the metabolic role of mitochondria during developmental leaf senescence

, 2016
The functions of mitochondria during leaf senescence, a type of programmed cell death aimed at the massive retrieval of nutrients from the senescing organ to the rest of the plant, remain elusive.
Gardeström, Per, Keech, Olivier, Moritz, Thomas, Ziolkowska, Agnieszka,, Szal, Bozena, Liebsch, Daniela,, Law, Simon R., Whelan, James, Liebsch, Daniela, Narsai, Reena, Ziolkowska, Agnieszka, Brouwer, Bastiaan,, Chrobok, Daria, Lindén, Pernilla, Gardeström, Per,, Law, Simon R.,, Brouwer, Bastiaan, Chrobok, Daria,, Keech, Olivier,, Brouwer, Bas, Rouhier, Nicolas   +20 more
core   +1 more source