Results 171 to 180 of about 380,324 (308)

Plastics to fertilizer: A polymer system based on isosorbide as a monomer, plasticizer, and fertilizer. [PDF]

Sci Rep
Fujimata S, Tokonami Y, Agrahari RK, Tsutsuba T, Rikiyama K, Tomotsu N, Taniguchi T, Kamiya T, Nishida M, Aoki D.   +9 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Consumer Acceptability of Animal-Source Food Alternatives: A Literature Review to Support the Transition to Sustainable, Healthy Diets. [PDF]

Curr Dev Nutr
Nordhagen S, Beal T, Herrero M, Neufeld LM, Sokourenko K, Xipsiti M.   +5 more
europepmc   +1 more source

Critical Photoperiod for Flower Bud Initiation in Everbearing Strawberry 'Summerberry' Plants Grown at High Temperatures(Plant Production Science, Horticultural Science)

Critical Photoperiod for Flower Bud Initiation in Everbearing Strawberry 'Summerberry' Plants Grown at High Temperatures(Plant Production Science, Horticultural Science)
application/pdf The critical photoperiod for inflorescence production and flower bud initiation in everbearing strawberry ( Fragaria×ananassa Duch. 'Summerberry') plants was investigated. Plants were grown in phytotrons controlled at day (6:00-18:00) and night (18:00-6:00) temperatures of 30 and 25℃, respectively, under photoperiods of 12, 13, 14, 15 ...
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture-Level Organization and Enables Generative Aroma Design. [PDF]

Adv Sci (Weinh)
Zhang J, Xing H, Pizio AD, Ke Q, Kou X, Zhang D.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Natural Products: Advances in Isolation, Characterization, Biological Activities, and Plant Protection Applications. [PDF]

Molecules
Elshafie HS.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Alternative Proteins on the Polish Plate: Consumer Acceptance, Current Challenges, and Future Perspectives. [PDF]

Foods
Choręziak A, Sikora D, Rzymski P.
europepmc   +1 more source