Mitochondrial iron homeostasis is required for azole tolerance in Candida albicans
The FEBS Journal, EarlyView.In Candida albicans, the deletion of MRS4, which encodes a mitochondrial iron importer, abolishes fluconazole tolerance and increases cidality during cotreatment with the iron chelator BPS, without altering MIC or synergy. Fluconazole‐treated mutants exhibit increased mitochondrial depolarisation, fragmentation and reduced mitochondrial density.
Wouter Van Genechten +4 more
wiley +1 more source
A randomized study comparing plant sterol- and soluble fiber-enriched soymilk with plain soymilk in adults with elevated LDL cholesterol. [PDF]
Eur J NutrBuranapin S +3 more
europepmc +1 more source
The FEBS Journal, EarlyView.Lipid droplets (LD) act as cellular ‘garbage trucks’ that transport cytosolic protein aggregates to the vacuole for degradation in yeast. Protein aggregates are docked to lipid droplets in a triacylglycerol‐dependent manner, transported through the cytoplasm, and transferred to the insoluble protein deposit (IPOD) at the vacuole.
Christoph Reiter +15 more
wiley +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Introduction Apical periodontitis (AP) is an inflammatory disease of the periapical tissues driven by host responses to endodontic infection, and systemic metabolic disturbances, such as high‐fat diet (HFD)–induced dysmetabolism, may exacerbate tissue destruction. This study aimed to determine how chronic HFD exposure alters periapical myeloid
Maryam Ghaffari +3 more
wiley +1 more source
Beyond Phytosterol Profiling in Greek Olive Oil: Biological Variability, Regulatory Interpretation and the Near-Threshold Sterolic Space. [PDF]
MoleculesDialyna I, Trantas E, Ververidis F.
europepmc +1 more source
Associations between diet quality and adult acne: A cross sectional study in the UK Biobank
Journal of the European Academy of Dermatology and Venereology, EarlyView.Mediterranean‐style diet adherence was associated with lower odds of adult acne, particularly in women. In men, a low‐carbohydrate, high‐meat dietary pattern showed higher odds. Cooked vegetables and yoghurt were inversely associated, whereas pork, skimmed milk and milk‐based desserts showed positive associations.
Bochen Li +7 more
wiley +1 more source
Modulation of sebocyte function in acne: A pathway‐inclusive review
Journal of the European Academy of Dermatology and Venereology, EarlyView.Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis +3 more
wiley +1 more source
Tailoring plant-based food emulsions with oil bodies and proteins recovered by alkali aqueous extraction from rapeseed (<i>Brassica napus</i> L.) oilseeds. [PDF]
Curr Res Food SciRabesona H, Lopez C.
europepmc +1 more source
Journal of Fish Biology, EarlyView.Abstract High‐latitude ecosystems are simultaneously warming and acidifying under ongoing climate change. Arctic cod (Boreogadus saida) are a key species in the Arctic Ocean and have demonstrated sensitivity to ocean warming and acidification as adults and embryos, but their larval sensitivity to the combined stressors is unknown. In a laboratory multi‐
Emily Slesinger +6 more
wiley +1 more source
Biallelic ABCG8 Variants or Biochemical Evidence of Sitosterolemia: A Case Report. [PDF]
CureusBurns J, Zachariah J.
europepmc +1 more source