Results 91 to 100 of about 7,909,977 (297)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Phytotoxic Effects of Bisphenol A on Growth and Physiology of Capsicum annuum L.
HorticulturaeBisphenol A (BPA) is a widely used chemical to produce raw materials in plastic production, which has led to its ubiquity in the natural environment and toxicity to both plants and humans.
Zilin Zhang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Plant Tissue Culture of Zingiberaceae (I)
Plant tissue culture letters, 1987 This report deals with an investigation of media and plant growth regulators for obtaining multiple plantlets of turmeric. Murashige-Skoog (MS)medium containing 10mg/l BA was effective for shoot formation. These shoots formed healthy roots on 1/2 MS medium containing 0.1mg/l NAA. Plantlets were tranferred to soil and healthily grew.
Makoto SATO +4 more
openaire +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
IN VITRO REGENERATION OF Aloe vera L. IN A NEW PLANT TISSUE CULTURE MEDIUM [PDF]
, 2022 A thesis Paper Submitted to the faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka in partial fulfillment of the requirements for the degree of MASTER OF SCIENCEThe experiment was conducted at the Biotechnology Laboratory ...
SARKER, CHHANDA
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Morphogenetic responses of pea leaflets cultured in vitro
, 1982 This investigation was undertaken in an attempt to study the morphogenetic responses of in vitro cultured immature leaflets of pea to various combinations of cytokinesis and auxins and to optimize the in vitro culture conditions in order to bring about ...
Rubluo, Abraham +2 more
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Plant Tissue Culture and Secondary Metabolite Production Volume II. [PDF]
Plants (Basel), 2023 Danova K, Marchioni I, Pistelli L.
europepmc +1 more source