Results 161 to 170 of about 62,237 (305)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Association of dietary intake patterns with treatment outcomes in late-stage pancreatic tumors. [PDF]

Front Nutr
Cui W, Tao Y, Zhang S, Zhou W, Liu Z.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Uterine Inflammatory Myofibroblastic Tumors: p16 as a Surrogate for CDKN2A Deletion and Predictor of Aggressive Behavior.

Uterine inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms of uncertain malignant potential. Aside from the recently described risk stratification score, which has not been validated by other studies, and rare reports of aberrant ...
Croce, Sabrina, Oliva, Esther, Pinto, Andre, Devins, Kyle M, Mendoza, Rachelle P, Haridas, Rishikesh, Wanjari, Pankhuri, Bennett, Jennifer A, Ordulu, Zehra   +8 more
core   +1 more source

Engineering Extracellular Vesicles for Tumor Targeted Therapy: Source Optimization, Modification, and Clinical Application. [PDF]

Int J Nanomedicine
Sui J, Qin H, Zhang Z, Lv X, Lin X, Liu Z, Zhao X, Liu X, Zhang H.   +8 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Research Progress and Preclinical Prospects of Plant-Derived Extracellular Vesicles in Targeted Delivery of Antitumor Drugs. [PDF]

Int J Nanomedicine
Huang D, Chen J, Shen H, Jin Q, Chen T, Xie Y, Rao D, Liu M.   +7 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The use of antisense RNA to inhibit gene expression in plant crown gall tumors

, 1991
Traditional approaches for studying gene function are not always applicable to multicellular eukaryotes. This is especially true for plants where there is currently no reliable method for gene replacement by homologous recombination.
Goodner, Bradley Wayne
core  

Anti-Tumor Activity of Stevia Leaf Extract Fermented by the Plant-Derived <i>Lactiplantibacillus plantarum</i> SN13T in a Pancreatic Tumor Xenograft Model. [PDF]

Antioxidants (Basel)
Zhang R, Danshiitsoodol N, Noda M, Sugiyama M.   +3 more
europepmc   +1 more source