Results 171 to 180 of about 62,237 (305)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Genomic, Transcriptomic, and Immunologic Landscape of HRAS Mutations in Solid Tumors

Tipifarnib is the only targeted therapy breakthrough for -mutant ( mt) recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). The molecular profiles of mt cancers are difficult to explore given the low frequency of mt.
Elliott, Andrew, Bustos, Matias A, Sledge, George, Samec, Timothy, Kareff, Samuel A, Trabolsi, Asaad, Goel, Sanjay, Rodriguez, Estelamari, Antonarakis, Emmanuel S, Olazagasti, Coral, Hoon, Dave S B, Graff, Stephanie L, Watson, Dionysios C, Lopes, Gilberto, Krause, Harris B   +14 more
core  

From Nature to Nanomedicine: Engineered Plant-Derived Nanovesicles for Skin Disease. [PDF]

Int J Nanomedicine
Yue Z, Yin J, Li Y.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

<i>Salvia miltiorrhiza</i>-derived microRNA58 inhibits tumor growth by targeting Krüppel-like factor 3 in human endothelial cells. [PDF]

Transl Cancer Res
Qin Y, Zhao M, Zhang J, Pei Y, Suo S, Wu M, Shi Y, Wu F, Shen Z, Li H, Zhang H, Zhang L.   +11 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Engineered Plant-Derived Extracellular Vesicles: A Novel Strategy for Tumor-Targeted Therapy. [PDF]

Pharmaceutics
Zuo Y, Zhang J, Wang X, Sun B, Tian S, Miao M.   +5 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Telomere-driven dysfunctional changes in gynecological cancers: mechanistic insights, biomarker potential, and therapeutic targeting. [PDF]

Front Cell Dev Biol
Afolabi OA, Alade TA, Olaniyi KS, Adeyemi MO, Oladepo S, Gbadero JO, Oyedokun MD, Olayemi SB, Akindele BM, Oladipo AA, Adegbola CA, Oghenetega OB, Akinsanya SY, Sotunsa J, Ogunleye OD, Lasisi-Sholola AS, Owolabi VP, Adewale O, Adewale J, Oke DA, Adelani Abdur-Rahman H, Oyedokun PA.   +21 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source