Results 191 to 200 of about 57,258 (243)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Plant-derived exosome-like nanovesicles: dual-function platforms for anticancer therapy and drug delivery. [PDF]

J Transl Med
Zuo Y, Zhang J, Wang X, Sun B, Tian S, Miao M.   +5 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

The Role of Estrogen Signaling Pathway and Targeted Therapy Exploration in Urological Tumors. [PDF]

Int J Biol Sci
Ma C, Yang L, Li W, Shangguan W, Huang W, Li Z, Sun B, Yang X, Xu H, Li Z, Peng P, Wang Z, Wu P, Cheng B.   +13 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Botanical Adjuvants in Oncology: A Review on Natural Compounds in Synergy with Conventional Therapies as Next-Generation Enhancers of Breast Cancer Treatment. [PDF]

Curr Issues Mol Biol
Mansouri H, Irchad A, Rubaka C, Kisula L, Hamza AA, Sauli E.   +5 more
europepmc   +1 more source

A Systematic Review of Advances in Plant-Based Phospholipid Liposomes in Breast Cancer Therapy: Characterization, Innovations, Clinical Applications, and Future Directions. [PDF]

Pharmaceuticals (Basel)
Alawi M, Hashim NM, Ahmad N, Mahmood S, Ge Y.   +4 more
europepmc   +1 more source

Deciphering the cancer chemopreventive potential of phytochemicals: an integrative perspective on molecular targets and signaling networks. [PDF]

Cancer Cell Int
Kaur S, Ahmad SS, Raja V, Mahajan P, Abdi G.   +4 more
europepmc   +1 more source

Methionine restriction in cancer: a dietary insight for therapy. [PDF]

Front Nutr
Tian X, Zhu G, Zhang Y, Liu N.
europepmc   +1 more source

Targeting Hippo-YAP/TAZ signaling pathway: an updated review demonstrating the therapeutic potential of key plant derived anticancer compounds. [PDF]

Front Pharmacol
Elsori D, Pandey P, Alshaikh K, Alkhathami AG, Saeed M, Singh A, Khan F.   +6 more
europepmc   +1 more source