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Therapeutic Interfering Particles Exploiting Viral Replication and Assembly Mechanisms Show Promising Performance: A Modelling Study [PDF]
Scientific Reports, 11, 23847 (2021), 2021 Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome. Their ability to replicate in the presence of the wild-type (WT) virus (at the expense of viable viral particles) is mimicked and exploited by therapeutic interfering particles.
arxiv +1 more source
Movement Protein of Cucumber Mosaic Virus Associates with Apoplastic Ascorbate Oxidase. [PDF]
PLoS ONE, 2016 Plant viral movement proteins facilitate virion movement mainly through interaction with a number of factors from the host. We report the association of a cell wall localized ascorbate oxidase (CsAO4) from Cucumis sativus with the movement protein (MP ...
Reenu Kumari +3 more
doaj +1 more source
Viruses, 2022 Remorin (REM) is a plant-specific plasma membrane-associated protein regulating plasmodesmata plasticity and restricting viral cell-to-cell movement.
Tingting Ma +5 more
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2016 Christiaan van der Schoot
openalex +2 more sources
Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and Budding [PDF]
Viruses 2022, 14, 2089, 2022 The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spurred unprecedented and concerted worldwide research to curtail and eradicate this pathogen. SARS-CoV-2 has four structural proteins: Envelope (E), Membrane (M), Nucleocapsid (N), and Spike (S), which self-assemble along with its RNA into the ...
arxiv +1 more source
A multitask transfer learning framework for the prediction of virus-human protein-protein interactions [PDF]
BMC Bioinformatics 2021, 2021 Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis. This could further help in the prevention and treatment of virus-related diseases.
arxiv +1 more source
Recent progress in research on cell-to-cell movement of rice viruses
Frontiers in Microbiology, 2014 To adapt to plants as hosts, plant viruses have evolutionally needed the capacity to modify the host plasmodesmata (PD) that connect adjacent cells. Plant viruses have acquired one or more genes that encode movement proteins (MPs), which facilitate the ...
Akihiro eHiraguri +4 more
doaj +1 more source
An Update on the Intracellular and Intercellular Trafficking of Carmoviruses
Frontiers in Plant Science, 2017 Despite harboring the smallest genomes among plant RNA viruses, carmoviruses have emerged as an ideal model system for studying essential steps of the viral cycle including intracellular and intercellular trafficking.
José A. Navarro, Vicente Pallás
doaj +1 more source
Role of electrostatic interactions in the assembly of empty spherical viral capsids [PDF]
Phys. Rev. E 76, 061906 (2007), 2007 We examine the role of electrostatic interactions in the assembly of empty spherical viral capsids. The charges on the protein subunits that make the viral capsid mutually interact and are expected to yield electrostatic repulsion acting against the assembly of capsids.
arxiv +1 more source
Plant Signaling & Behavior, 2009 Plant viruses are composed of diverse genomes (e.g., RNA or DNA) encoding proteins that vary widely in sequence. It is becoming clear, however, that some apparently unrelated viral proteins have similar functions. The P6 protein encoded by Cauliflower mosaic virus (CaMV) and the 126-kDa protein encoded by Tobacco mosaic virus (TMV) are examples of this
Richard S. Nelson +2 more
openaire +3 more sources