Results 131 to 140 of about 185,176 (316)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Involvement of cathepsin B in the plant disease resistance hypersensitive response

, 2007
A diverse range of plant proteases are implicated in pathogen perception and in subsequent signalling and execution of disease resistance. We demonstrate, using protease inhibitors and virus-induced gene silencing (VIGS), that the plant papain cysteine ...
Shaw, Jane, Hein, I., Christophe Lacomme, Kaffarnik, Florian, Hein, Ingo, Lopez, Eduardo C., Eduard Venter, Van Der Hoorn, Renier, Paul R. J. Birch, Pritchard, L., Borras-Hidalgo, Orlando, Hazel McLellan, Gilroy, Eleanor M., McLellan, H., Eleanor M. Gilroy, Hrubikova, Katarina, Birch, P., Orlando Borras-Hidalgo, Boevink, P., Eduardo C. López, Shaw, J., Maria Holeva, Jane Shaw, Loake, Gary J., Hrubikova, K., Katarina Hrubikova, Boevink, Petra C., Holeva, Maria, Venter, Eduard, Kaffarnik, F., McLellan, Hazel, Van der Hoorn, R., Venter, E., Lopez, E., Gary J. Loake, Hein, Ingo; id_orcid, Florian Kaffarnik, Renier Van Der Hoorn, Birch, Paul R. J.; id_orcid, Lacomme, Christophe, Loake, G., Borras-Hidalgo, O., Pritchard, Leighton, Lacomme, C., Ingo Hein, Birch, Paul R. J., Leighton Pritchard, Holeva, M., Gilroy, E., Petra C. Boevink   +49 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Investigation of a rapid screening method to study the effects of the snowdrop lectin (Galanthus nivalis Agglutinin) on plant pathogens [PDF]

, 2002
Two Tobravirus expression vectors were evaluated for the use as a rapid screening method for anti-nutritional proteins against plant pathogens. Accumulation of green fluorescent protein (GFP) and snowdrop lectin gene (Galanthus nivalis agglutinin ...
Popovich, Alexandra Helen
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

RNA-dependent RNA polymerase 6 of rice (Oryza sativa) plays role in host defense against negative-strand RNA virus, Rice stripe virus

, 2012
RNA-dependent RNA polymerases (RDRs) from fungi, plants and some invertebrate animals play fundamental roles in antiviral defense. Here, we investigated the role of RDR6 in the defense of economically important rice plants against a negative-strand RNA ...
Chun-Hong Wei, Le, Wen-Jing, Lin-Yan Meng, Meng, Lin-Yan, Zhou, Tong, Hong Zheng, Jiang, Lin, Jie Chen, Chen, Jie, Li, Yi, Wen-Jing Le, Lin Jiang, Tong Zhou, Yi-Jun Zhou, Qian, Dan, Wei, Chun-Hong, Yi Li, Zhou, Yi-Jun, Zheng, Hong, Dan Qian   +19 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Potato leafroll virus, its purification from its vector Myzus persicae

, 1967
Experiments were described on the purification of potato leafroll virus (PLRV) from its vector Myzus persicae. Preliminary experiments demonstrated that much non- viral material had to be removed from aphid macerates to obtain a pure virus preparation ...
Peters, D.
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source