Results 141 to 150 of about 5,677,108 (410)
Molecular Oncology, EarlyView.Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger +2 more
wiley +1 more source
Using Computer Vision to enhance Safety of Workforce in Manufacturing in a Post COVID World [PDF]
arXiv, 2020 The COVID-19 pandemic forced governments across the world to impose lockdowns to prevent virus transmissions. This resulted in the shutdown of all economic activity and accordingly the production at manufacturing plants across most sectors was halted. While there is an urgency to resume production, there is an even greater need to ensure the safety of ...
arxiv
New Phytologist, 2016 It has been hypothesized that plant-virus interactions vary between antagonism and conditional mutualism according to environmental conditions. This hypothesis is based on scant experimental evidence, and to test it we examined the effect of abiotic ...
J. hily +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
How a Virus Circumvents Energy Barriers to Form Symmetric Shells [PDF]
arXiv, 2020 Previous self-assembly experiments on a model icosahedral plant virus have shown that, under physiological conditions, capsid proteins initially bind to the genome through an en masse mechanism and form nucleoprotein complexes in a disordered state, which raises the questions as to how virions are assembled into a highly ordered structure in the host ...
arxiv
Plant Virus–Insect Vector Interactions: Current and Potential Future Research Directions
Viruses, 2016 Acquisition and transmission by an insect vector is central to the infection cycle of the majority of plant pathogenic viruses. Plant viruses can interact with their insect host in a variety of ways including both non-persistent and circulative ...
R. Dietzgen +2 more
semanticscholar +1 more source
Virus resistance genes in plants
Uirusu, 2018 Plants defend themselves from virus infection by RNA silencing and resistance (R) gene-mediated mechanisms. Many dominant R genes encode nucleotide-binding site and leucine-rich repeat (NB-LRR)-containing proteins. NB-LRR proteins are also encoded by R genes against bacteria or fungi, suggesting a similar mechanism underlies defense systems to diverse ...
Kazuhiro Ishibashi, Masayuki Ishikawa
openaire +3 more sources
Hypersensitive response to Potato virus Y in potato cultivar Sárpo Mira is conferred by the Ny-Smira gene located on the long arm of chromosome IX [PDF]
, 2014 Potato virus Y (PVY, Potyvirus) is the fifth most important plant virus worldwide in terms of economic and scientific impact. It infects members of the family Solanaceae and causes losses in potato, tomato, tobacco, pepper and petunia production.
Hein, Ingo +4 more
core +3 more sources
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Application of Mathematical Epidemiology to crop vector-borne diseases. The cassava mosaic virus disease case [PDF]
arXiv, 2019 In this chapter, an application of Mathematical Epidemiology to crop vector-borne diseases is presented to investigate the interactions between crops, vectors, and virus. The main illustrative example is the cassava mosaic disease (CMD). The CMD virus has two routes of infection: through vectors and also through infected crops.
arxiv