Results 161 to 170 of about 137,452 (295)

Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim   +9 more
wiley   +1 more source

Complete Genome Sequence of Turnip yellows polerovirus from Iraq: Insight into the Factors Affecting the Genetic Variability of TuYV Populations

open access: yesMaǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ
Turnip yellows virus (TuYV), is one of the most important viruses belonging to the Polerovirus genus. Incidence, genetic variability, and population structure of TuYV have not yet been studied in mid-Eurasia Iraq.
Muhannad Al-Waeli   +2 more
doaj   +2 more sources

Cellular fate of a plant virus immunotherapy candidate. [PDF]

open access: yesCommun Biol
Omole AO   +13 more
europepmc   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo   +11 more
wiley   +1 more source

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani   +11 more
wiley   +1 more source

A plant virus manipulates both its host plant and the insect that facilitates its transmission. [PDF]

open access: yesSci Adv
Liang P   +14 more
europepmc   +1 more source

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