Results 111 to 120 of about 5,423,022 (349)

The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses

Nature Structural &Molecular Biology, 2015
Flexible filamentous plant viruses cause more than half the viral crop damage in the world but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed, owing to the virion's extreme flexibility.
F. DiMaio, Chun-Chieh Chen, Xiong Yu, Brandon Frenz, Y. Hsu, N. Lin, E. Egelman   +6 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants

Vaccines, 2015
Vaccines are considered one of the greatest medical achievements in the battle against infectious diseases. However, the intractability of various diseases such as hepatitis C, HIV/AIDS, malaria, tuberculosis, and cancer poses persistent hurdles given ...
Marie-Ève Lebel, Karine Chartrand, D. Leclerc, A. Lamarre   +3 more
semanticscholar   +1 more source

Attomolar electrochemical direct and sandwich immunoassays for the ultrasensitive detection of tomato brown rugose fruit virus

Plant Methods
Tomato brown rugose fruit virus (TBRFV; Tobamovirus fructirugosum) is a highly virulent tobamovirus that has emerged as a major global threat to tomato and pepper crops over the past decade.
Negin Rezaei, Ahmad Moshaii, Mohammad Reza Safarnejad, Reza H. Sajedi, Mahsa Rahmanipour, Masoud Shams-Bakhsh   +5 more
doaj   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Bioinspired optical antennas: gold plant viruses

Light: Science & Applications, 2015
The ability to capture the chemical signatures of biomolecules (i.e., electron-transfer dynamics) in living cells will provide an entirely new perspective on biology and medicine. This can be accomplished using nanoscale optical antennas that can collect,
SoonGweon Hong, Mi Yeon Lee, A. O. Jackson, Luke P. Lee   +3 more
semanticscholar   +1 more source

Exploring Virus Diversity in the Potato leafhopper (Empoasca fabae), an Economically Important Agricultural Pest

Viruses
The potato leafhopper (Empoasca fabae, PLH) is a serious pest that feeds on a wide range of agricultural crops and is found throughout the United States but is not known to be a vector for plant-infecting viruses.
Thanuja Thekke-Veetil, Doris Lagos-Kutz, Leslie L. Domier, Nancy K. McCoppin, Glen L. Hartman, Steven J. Clough   +5 more
doaj   +1 more source

Populations of parasitic nematodes colonizing Jerusalem artichoke (Helianthus tuberosus L.)

Acta Societatis Botanicorum Poloniae, 2018
The populations of parasitic nematodes colonizing the rhizosphere of Helianthus tuberosus L. grown in Polish plantations were studied in the summer of 2016 and the spring of 2017.
Anita Zapałowska, Andrzej Tomasz Skwiercz   +1 more
doaj   +1 more source

Mechanisms of Resistance to Plant Viruses

Annual Review of Phytopathology, 1986
Peer ...
Ponz Ascaso, Fernando, Bruening, G.
openaire   +3 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source