Results 111 to 120 of about 5,712,318 (385)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Stability of recombinant plant viruses containing genes of unrelated plant viruses

Journal of General Virology, 2007
The stability of hybrid plant viruses that might arise by recombination in transgenic plants was examined using hybrid viruses derived from the viral expression vectors potato virus X (PVX) and tobacco rattle virus (TRV). The potato virus Y (PVY) NIb and HCPro open reading frames (ORFs) were introduced into PVX to generate PVX-NIb and PVX-HCPro, while ...
Chung, Bong-Nam, Canto, Tomas, Palukaitis, Peter   +2 more
openaire   +4 more sources

Distinct modes of manipulation of rice auxin response factor OsARF17 by different plant RNA viruses for infection

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Auxin signaling plays essential roles in almost every aspect of plant growth and development. Auxin response factors (ARFs) are key transcriptional regulators of auxin signaling.
Hehong Zhang, Lulu Li, Yuqing He, Qingqing Qin, Changhai Chen, Zhongyan Wei, Xiaoxiang Tan, Kaili Xie, Ruifang Zhang, G. Hong, Jing Li, Junmin Li, Chengqi Yan, Fei Yan, Yi Li, Jianping Chen, Zongtao Sun   +16 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A Framework for the Evaluation of Biosecurity, Commercial, Regulatory, and Scientific Impacts of Plant Viruses and Viroids Identified by NGS Technologies

Frontiers in Microbiology, 2016
Recent advances in high-throughput sequencing technologies and bioinformatics have generated huge new opportunities for discovering and diagnosing plant viruses and viroids.
S. Massart, T. Candresse, J. Gil, C. Lacomme, L. Predajňa, M. Ravnikar, J. Reynard, A. Rumbou, P. Saldarelli, D. Škorić, E. Vainio, J. Valkonen, H. Vanderschuren, C. Varveri, T. Wetzel   +14 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Temporal Dynamics of Soil Virus and Bacterial Populations in Agricultural and Early Plant Successional Soils [PDF]

, 2020
Krishnakali Roy, Dhritiman Ghosh, Jennifer M. DeBruyn, Tirthankar Dasgupta, K. Eric Wommack, Xiaolong Liang, Regan E. Wagner, Mark Radosevich   +7 more
openalex   +1 more source

Recessive Resistance to Plant Viruses: Potential Resistance Genes Beyond Translation Initiation Factors

Frontiers in Microbiology, 2016
The ability of plant viruses to propagate their genomes in host cells depends on many host factors. In the absence of an agrochemical that specifically targets plant viral infection cycles, one of the most effective methods for controlling viral diseases
M. Hashimoto, Y. Neriya, Y. Yamaji, S. Namba   +3 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Night at the museum: Contribution of small RNA from historical herbarium specimens in the reconstruction of evolutionary histories of geminiviruses [PDF]

, 2019
Emerging infectious diseases of plants, almost half of which are caused by viruses, are recognized as a growing threat to global food security. However, little is known about the evolutionary processes and ecological factors that underlie the emergence ...
Becker, Nathalie, Campos, Paola, Duvermy, Arnaud, Filloux, Denis, Lett, Jean-Michel, Martin, Darren Patrick, Rieux, Adrien, Roumagnac, Philippe, Scussel, Sarah   +8 more
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