Results 71 to 80 of about 66,062 (256)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Alternate wetting and drying irrigation for rice in Bangladesh: Is it sustainable and has plant breeding something to offer? [PDF]

, 2013
The crop management practice of alternate wetting and drying (AWD) is being promoted by IRRI and the national research and extension program in Bangladesh and other parts of the world as a water-saving irrigation practice that reduces the environmental ...
Price, Adam H., Ismail, Abdelbagi M., Meharg (nee Reiff), Caroline, Ismail, Abdelbagi M, Dasgupta, Tapash, Islam, M. Rafiqul, Dodd, Ian C., Salt, David E., Norton, Gareth J., Davies, William J., Salt, David E, Price, Adam H, Davies, William J, Sarna, Ramen N., Zhang, Hao, Norton, Gareth J, Islam, M Rafiqul, Meharg, Andrew A.; id_orcid, Dodd, Ian C, Sarma, Ramen N, Meharg, Caroline, Ebenhöh, Oliver, Meharg, Andrew A, McNally, Kenneth L., McNally, Kenneth L, Ebenhoeh, Oliver   +25 more
core   +1 more source

Changes of Sabina vulgaris growth and of soil moisture in natural stands and plantations in semi-arid northern China

Global Ecology and Conservation, 2020
To better understand the adaptability of Sabina vulgaris in the southeastern margin of China’s Mu Us Sandy Land to climate change, we observed plant growth and soil moisture to a depth of 100 cm in natural stands and plantations for 2 years.
Weige Nan, Shengquan Liu, Shujun Yang, Zhibao Dong, Junhuai Yang, Weikang Shi   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A simple soil water content measurement system for plant cultivation

Agrosystems, Geosciences & Environment
Precise nondestructive methods for monitoring soil water content (SWC) are essential for maintaining plant growth and metabolic activity. In this study, an inductance‐based monitoring system was developed using a solenoid‐coil sensor for continuous in ...
Ye Jin Kim, Jeong Wook Jo, Jae Hun Kim, Gyu Won Lee, Kwang Jin Kim, Ho Hyun Kim, Hyung Joo Kim   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Root developmental responses to heterogeneous water and nitrogen supply [PDF]

, 2012
Better understanding of the interaction between the soil physical properties determining water and nitrate availability and the root proliferation and gene expression components of nutrient acquisition could contribute to food security, but may have been
Chapman, N., CHAPMAN, NICHOLAS
core  

Validation of a spatial-temporal soil water movement and plant water uptake model [PDF]

, 2014
Management and irrigation of plants increasingly relies on accurate mathematical models for the movement of water within unsaturated soils. Current models often use values for water content and soil parameters that are averaged over the soil profile ...
Roose, T., Payvandi, S., Zygalakis, K.C., Fliege, J., Heppell, J., Smethurst, J.A.   +5 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source