Results 131 to 140 of about 11,010,391 (302)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Water in the 2010 Virginia General Assembly

, 2010
The 2010 Virginia General Assembly convened January 13 and adjourned March 13. The reconvened (“veto”) session was held April 21. During the session, the Assembly considered 2964 measures, passing 1598 of them, defeating 1093, and continuing 273 until ...
Virginia Water Resources Research Center
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Investigating the mechanisms of desiccation tolerance in the resurrection plant, myrothamnus flabellifolius (WELW) [PDF]

, 1999
Biliography : leaves 162-184.Resurrection plants, including Myrothamnus flabellifolius, grow in shallow soil upon rocky outcrops where they experience regular periods of water stress. Associated with this is light stress.
Koonjul, Priyum K
core   +1 more source

Nitrogen isotope ratio (δ15N): a nearly unexplored indicator that provides useful information in viticulture

OENO One
The study of the natural abundance of nitrogen-stable isotopes is an aspect of viticulture research that has received limited attention. While stable isotopes of carbon, oxygen and hydrogen have received significant attention, nitrogen isotope ratio ...
Luis Gonzaga Santesteban, Maite Loidi, Inés Urretavizcaya, Mónica Galar, Sara Crespo-Martínez, José Bernardo Royo, Carlos Miranda   +6 more
doaj   +1 more source

The Volume of Water Bills in the 1999 Virginia General Assembly

, 1999
The Virginia General Assembly held its 1999 session from January 13 to February 27. During the regular session, lawmakers considered 2,735 bills and resolutions, compared to 2945 measures considered in the longer 1998 session.
Virginia Water Resources Research Center
core  

A biomarker based on gene expression indicates plant water status in controlled and natural environments.

, 2013
International audiencePlant or soil water status is required in many scientific fields to understand plant responses to drought. Because the transcriptomic response to abiotic conditions, such as water deficit, reflects plant water status, genomic tools ...
Langlade, Nicolas, Mayjonade, Baptiste, Maury, Pierre, Boniface, Marie-Claude, Debaeke, Philippe, P., Blanchet, Nicolas, Casadebaig, Pierre, Marchand, Gwenaëlle, Andrianasolo, Fety, Vares, Didier, Vincourt, Patrick, P., Burger, Philippe   +11 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Water in the 2005 Virginia General Assembly

, 2005
The 2005 Virginia General Assembly convened January 12 and adjourned February 27, with a reconvened (“veto”) session on April 6. The legislature considered 3363 measures (2938 introduced this year and 425 carried over from last year); 1610 measures ...
Virginia Water Resources Research Center
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source