Results 141 to 150 of about 11,010,391 (302)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

[Water Department Employees at White Rock Plant]

, 1952
Photograph of Dallas Water Department employees at White Rock Purification Plant. A handwritten note on the reverse of the photograph reads: "Showing settling basin in background as water dept employees put White Rock plant into operation again.
Dallas (Tex.)
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Water status diagnosis in greenhouse drip-irrigated tomato and celery using leaf turgor dynamics and machine learning

Frontiers in Plant Science
IntroductionAccurate crop water status monitoring is crucial for optimized irrigation in controlled environments, but traditional approaches relying on damaging measurements or sporadic sampling frequently restrict real-time evaluation.MethodsThis study ...
Quanyue Xu, Quanyue Xu, Ruixia Chen, Ruixia Chen, Xufeng Li, Xufeng Li, Hongxiang Wu, Hongxiang Wu, Juanjuan Ma, Juanjuan Ma, Lijian Zheng, Lijian Zheng   +11 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Linking plant water status dynamics to yield and fruit cracking in citrus orchards using UAV multi-sensor data and machine learning

Agricultural Water Management
Citrus fruit cracking causes substantial yield and economic losses, yet its relationship with plant water status (PWS) and irrigation management remains insufficiently characterized.
Moshe (Vladislav) Dubinin, Michael Morozov, Ohaliav Keisar, Guy Lidor, Victor Alchanatis, Avi Sadka, Tarin Paz-Kagan   +6 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Mid-Season Yield Estimation in High-Productivity Vineyards: A Preliminary Modeling Framework for Free-Canopy Systems

Agronomy
Accurate vineyard yield estimation is essential for harvest planning, resource allocation, and economic decision-making, particularly under conditions of high spatial variability.
César Acevedo-Opazo, Paulo Cañete-Salinas, Miguel Araya-Alman, Cristian Ackerknecht-Espinosa, Lucas Vásquez, Yerko Moreno-Simunovic   +5 more
doaj   +1 more source

1998 General Assembly Legislation Related to Water

, 1998
The Virginia General Assembly held its regular session from January 14 to March 17, then reconvened April 22-23 to respond to the governor’s vetoes.
Manfre, Joseph, Virginia Water Resources Research Center   +1 more
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source