Results 91 to 100 of about 201,967 (310)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
THE SAFETY ASSESSMENT OF MEDICINAL PLANTS
Безопасность и риск фармакотерапии, 2018 The problems of safety evaluation of medicinal plants formulations in the Russian Federation, Europe and USA are presented. Safety issues of medicinal plants, as well as the adverse reactions of some herbal medicines are discussed.
E. V. Shikh +2 more
doaj
Phyto-metals screening of selected anti-diabetic herbs and infused concoctions
Asian Pacific Journal of Tropical Biomedicine, 2017 Objective: To determine the levels of some selected heavy metals in both the selected anti-diabetic herbal plants and infused concoctions for diabetes treatment. Methods: Ten anti-diabetic plant samples: pawpaw leaves (Carica papaya), bitter melon leaves
Olanrewaju O. Olujimi +5 more
doaj +1 more source
, 2010 Rapid administration of stable iodine is essential for the saturation and subsequent protection of the thyroid gland against the potential harm caused by radioiodines.
Meulenbelt, J. +4 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Retrospective analysis of cattle poisoning in Argentina (2000-2013)
Pesquisa Veterinária Brasileira: A retrospective analysis (2000 to 2013) of cattle poisoning caused by toxic plants and other compounds was carried out in the Pampas region of Argentina by the Animal Health Group of INTA-EEA, Balcarce.
Juan A. García +6 more
doaj +1 more source
, 1996 This item is a zipped archive of html files and images that constitute the toxic plants database. To use these files, download the zipped file and unzip it. In a web browser, open the "index.html" file found in the top level, "toxic," directory. The rest
Williams, Mitsuko +1 more
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Ethnomedicinal Analysis of Toxic Plants from Five Ethnic Groups in China [PDF]
, 2010 researchToxic plants are important elements of ethnomedicine. Ethnomedicinal knowledge on toxic plants recorded from five indigenous people, Dai, Lahu, Miao, Tujia, and Wa in south and southwestern China, was summarized and analyzed based on available ...
Huyin Huai, Aizhong Liu, Qinqin Dong
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